Authoritative and reliable, this AZ provides jargon-free definitions for even the most technical
mathematical terms. With over 3,000 entries ranging from Achilles paradox to zero matrix, it …

Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it
defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 …

Background Gain of genetic material from chromosome arm 17q (gain of segment 17q21–qter)
is the most frequent cytogenetic abnormality of neuroblastoma cells. This gain has been …

Glioma intratumoral heterogeneity and malignant cell state plasticity represent formidable
hurdles to the development of novel targeted therapies. However, the convergence of …

Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium
may contribute to these functions directly or by cross-talk with immune cells. We used …

Background We conducted a nonrandomized international study for intracranial germinoma
that compared chemotherapy followed by local radiotherapy with reduced-dose craniospinal …

Ewing’s tumors are rare pediatric neoplasms that are characterized by specific chromosomal
translocations and gene rearrangements. All of the fusion genes reported to date in Ewing’…

Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors
(GCT) are thought to originate from primordial germ cells. However, no common biological …

A simple-to-use fluorescent stain, 4′,6-diamidino-2-phenylindole (DAPI), visualizes nuclear
DNA in both living and fixed cells. DAPI staining was used to determine the number of …

The management of intracranial germ-cell tumours is complex because of varied clinical
presentations, tumour sites, treatments and outcomes, and the need for multidisciplinary input. …