Posterior capsule opacification

…, EI Assia, EY Holland, UFC Legler, JC Tsai… - Survey of …, 1992 - Elsevier
A complication of extracapsular cataract extraction with or without posterior chamber intraocular
lens (PC-IOL) implantation is posterior capsule opacification. This condition is usually …

Epithelial–mesenchymal plasticity in carcinoma metastasis

JH Tsai, J Yang - Genes & development, 2013 - genesdev.cshlp.org
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: …

Vemurafenib: the first drug approved for BRAF-mutant cancer

G Bollag, J Tsai, J Zhang, C Zhang, P Ibrahim… - Nature reviews Drug …, 2012 - nature.com
The identification of driver oncogenes has provided important targets for drugs that can
change the landscape of cancer therapies. One such example is the BRAF oncogene, which is …

Complement factor H polymorphism in age-related macular degeneration

RJ Klein, C Zeiss, EY Chew, JY Tsai, RS Sackler… - Science, 2005 - science.org
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We
report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with …

[HTML][HTML] Single-dose psilocybin for a treatment-resistant episode of major depression

…, D Sterling, A Strockis, J Tsai… - … England Journal of …, 2022 - Mass Medical Soc
Background Psilocybin is being studied for use in treatment-resistant depression. Methods
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant …

[HTML][HTML] Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging

…, S Kemp, S Christensen, JP Tsai… - … England Journal of …, 2018 - Mass Medical Soc
Background Thrombectomy is currently recommended for eligible patients with stroke who
are treated within 6 hours after the onset of symptoms. Methods We conducted a multicenter, …

Coherent control of macroscopic quantum states in a single-Cooper-pair box

Y Nakamura, YA Pashkin, JS Tsai - nature, 1999 - nature.com
… the Josephson energy E J from the oscillation period T coh as E J = h/T coh and investigated
its magnetic-field dependence (filled circles in Fig. 4 inset). We also measured E J in the …

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

G Bollag, P Hirth, J Tsai, J Zhang, PN Ibrahim, H Cho… - Nature, 2010 - nature.com
B-RAF is the most frequently mutated protein kinase in human cancers 1 . The finding that
oncogenic mutations in BRAF are common in melanoma 2 , followed by the demonstration …

High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial

…, ML Larsen, FS Bendiksen, C Lindahl, M Szarek, J Tsai… - Jama, 2005 - jamanetwork.com
ContextEvidence suggests that more intensive lowering of low-density lipoprotein cholesterol
(LDL-C) than is commonly applied clinically will provide further benefit in stable coronary …

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

J Tsai, JT Lee, W Wang, J Zhang… - Proceedings of the …, 2008 - National Acad Sciences
BRAF V600E is the most frequent oncogenic protein kinase mutation known. Furthermore,
inhibitors targeting “active” protein kinases have demonstrated significant utility in the …