Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
…, CM Astle, K Flurkey, NL Nadon, JE Wilkinson… - nature, 2009 - nature.com
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends
lifespan in invertebrates, including yeast, nematodes and fruitflies 1 , 2 , 3 , 4 , 5 ; however, …
lifespan in invertebrates, including yeast, nematodes and fruitflies 1 , 2 , 3 , 4 , 5 ; however, …
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
…, B Paeper, LB Clark, SA Yasayko, JE Wilkinson… - Nature …, 2001 - nature.com
Scurfy (sf) is an X-linked recessive mouse mutant resulting in lethality in hemizygous males
16–25 days after birth, and is characterized by overproliferation of CD4+ CD8–T lymphocytes…
16–25 days after birth, and is characterized by overproliferation of CD4+ CD8–T lymphocytes…
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
…, D Sinclair, JW Starnes, JE Wilkinson… - … Series A: Biomedical …, 2011 - academic.oup.com
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9
months and produced significant increases in life span, including maximum life span, at each …
months and produced significant increases in life span, including maximum life span, at each …
[HTML][HTML] Multivariable association discovery in population-scale meta-omics studies
…, KN Thompson, JE Wilkinson… - PLoS computational …, 2021 - journals.plos.org
It is challenging to associate features such as human health outcomes, diet, environmental
conditions, or other metadata to microbial community measurements, due in part to their …
conditions, or other metadata to microbial community measurements, due in part to their …
Rapamycin slows aging in mice
JE Wilkinson, L Burmeister, SV Brooks, CC Chan… - Aging cell, 2012 - Wiley Online Library
… Wilkinson… Harrison, Nadon, Miller, Strong, and Wilkinson designed the study. Dr.
Wilkinson performed all of the pathology examinations and interpreted the necropsy results. Ms. …
Wilkinson performed all of the pathology examinations and interpreted the necropsy results. Ms. …
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1
(metastasis-associated lung adenocarcinoma transcript 1) is among the most abundant …
(metastasis-associated lung adenocarcinoma transcript 1) is among the most abundant …
X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.
VL Godfrey, JE Wilkinson, LB Russell - The American journal of …, 1991 - ncbi.nlm.nih.gov
Scurfy (sf) is a spontaneous, sex-linked, recessive mutation that maps to the extreme proximal
portion of the X chromosome, about 2 centimorgans from sparse fur (spf). Hemizygotes for …
portion of the X chromosome, about 2 centimorgans from sparse fur (spf). Hemizygotes for …
The DNA sequence and biological annotation of human chromosome 1
…, JM Wallis, S White, SL Whitehead, JE Wilkinson… - Nature, 2006 - nature.com
The reference sequence for each human chromosome provides the framework for understanding
genome function, variation and evolution. Here we report the finished sequence and …
genome function, variation and evolution. Here we report the finished sequence and …
Thirty Years of Ageism Research Jody A. Wilkinson and Kenneth F. Ferraro
JA Wilkinson - Ageism: Stereotyping and prejudice against older …, 2004 - books.google.com
Robert N. Butler, former director of the National Institute on Aging, coined the term ageism (1969).
He identified age discrimination when the District of Columbia proposed a public …
He identified age discrimination when the District of Columbia proposed a public …
Asparagine bioavailability governs metastasis in a model of breast cancer
…, CS D'Santos, LA Carey, JE Wilkinson… - Nature, 2018 - nature.com
Using a functional model of breast cancer heterogeneity, we previously showed that clonal
sub-populations proficient at generating circulating tumour cells were not all equally capable …
sub-populations proficient at generating circulating tumour cells were not all equally capable …