Background Although the malaria burden has substantially decreased in sub-Saharan Africa,
progress has stalled. We assessed whether mass administration of ivermectin (a …

Background Conserved pneumococcal proteins are potential candidates for inclusion in
vaccines against pneumococcal diseases. In the first part of a two-part study, an investigational …

Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae, an
opportunistic human-adapted pathogen, is driven principally by nasopharyngeal carriage. …

The effectiveness of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine
(IPTp-SP) against malaria and anemia is unclear because of the spread of SP-…

Pregnancy in sickle cell disease (SCD) patients is associated with increased risk of maternal
and fetal mortality. This study determines pregnancy outcomes among women with SCD …

There is growing concern that interventions that alter microbial ecology can adversely affect
health. We characterised the impact of the seven-valent pneumococcal conjugate vaccine (…

Background The Gambia has successfully reduced malaria transmission. The human reservoir
of infection could further decrease if malaria-infected individuals could be identified by …

Background With a decline in malaria burden, innovative interventions and tools are required
to reduce malaria transmission further. Mass drug administration (MDA) of artemisinin-…

Background: Lifestyle intervention decreases diabetes risk in prediabetic subjects, but the
impact of passive notification of prediabetes status on glycemia or health behavior is unclear. …

Background In West Africa, the carriage of Group B Streptococcus (GBS), among infants is
poorly characterised. We investigated co-carriage of GBS with other respiratory pathogens in …