Purpose: Development of new therapeutic drug delivery systems is an area of significant
research interest. The ability to directly target a therapeutic agent to a tumor site would minimize …

Current assessment of orthotopic tumor models in animals utilizes survival as the primary
therapeutic end point. In vivo bioluminescence imaging (BLI) is a sensitive imaging modality …

The theory behind informed consent presumes that patients will use the information disclosed
in autonomous and rational ways. Unfortunately, this presumption is not always fulfilled in …

Objective: To determine whether a minimally invasive, colon-preserving approach could
serve as an alternative to total colectomy in the treatment of severe, complicated Clostridium …

Although existing measures of religiousness are sophisticated, no single approach has yet
emerged as a standard. We review the measures of religiousness most commonly used in …

The traditional interpretation of “intrinsic” religiousness has fostered an unchallenged
assumption that normative and substantive religious motivation is inherently individual and …

Strict coordination of proliferation and programmed cell death (apoptosis) is essential for
normal physiology. An imbalance in these two opposing processes results in various diseases …

Importance Growing consensus suggests that frailty-associated risks should inform shared
surgical decision making. However, it is not clear how best to screen for frailty in preoperative …

Importance As the US population ages, the number of operations performed on elderly patients
will likely increase. Frailty predicts postoperative mortality and morbidity more than age …

Importance Patients with frailty have higher risk for postoperative mortality and complications;
however, most research has focused on small groups of high-risk procedures. The …