Background A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of
vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a …

To gain insights into the pathogenesis and management of perinatal hypoxic‐ischemic brain
damage, the authors have used an immature rat model which they developed many years …

Background It is unknown whether inhaled corticosteroids can modify the subsequent
development of asthma in preschool children at high risk for asthma. Methods We randomly …

Wheezing is a fairly common symptom in early childhood, but only some of these toddlers will
experience continued wheezing symptoms in later childhood. The definition of the asthma-…

BACKGROUND: Few studies have characterized the atopic profile of toddler-aged children
with recurrent wheezing at high risk of the development of persistent asthma. OBJECTIVE: …

Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…

Background For children who have uncontrolled asthma despite the use of low-dose inhaled
corticosteroids (ICS), evidence to guide step-up therapy is lacking. Methods We randomly …

Background Severe asthma is a complex heterogeneous disease associated with older age
and obesity. The presence of eosinophilic (type 2) inflammation in some but not all patients …

Rationale: Reducing asthma exacerbation frequency is an important criterion for approval of
asthma therapies, but the clinical features of exacerbation-prone asthma (EPA) remain …

BACKGROUND. The link between mucus plugs and airflow obstruction has not been established
in chronic severe asthma, and the role of eosinophils and their products in mucus plug …