Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial
remodeling and accumulation of extracellular matrix (ECM). To comprehensively define …

Rationale: Maintenance of a surface immune barrier is important for homeostasis in organs
with mucosal surfaces that interface with the external environment; however, the role of the …

Objective: To evaluate the effect of video laryngoscopy on the rate of endotracheal intubation
on first laryngoscopy attempt among critically ill adults. Design: A randomized, parallel-…

Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary disease
(COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) deficiency in …

Sarcoidosis pathogenesis is characterized by peripheral anergy and an exaggerated,
pulmonary CD4+ Th1 response. In this study, we demonstrate that CD4+ anergic responses to …

Emerging evidence indicates that early life events can increase the risk for developing chronic
obstructive pulmonary disease (COPD). Using an inducible transgenic mouse model for …

Importance Sarcoidosis is a chronic granulomatous disease for which there are limited
therapeutic options. This is the first randomized, placebo-controlled study to demonstrate that …

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus
disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 …

Club cells are found in human small airways where they play an important role in immune
defense, xenobiotic metabolism, and repair after injury. Over the past few years, data from …

Rationale: Lung natural killer cells (NKs) kill a greater percentage of autologous lung
parenchymal cells in chronic obstructive pulmonary disease (COPD) than in nonobstructed …