Thrombotic thrombocytopenic purpura (TTP) is a life-threatening systemic illness of abrupt
onset and unknown cause. Proteolysis of the blood-clotting protein von Willebrand factor (VWF…

Group A streptococci, a common human pathogen, secrete streptokinase, which activates
the host's blood clot–dissolving protein, plasminogen. Streptokinase is highly specific for …

The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism
in response to nutrients, energy levels, and growth factors. It contains the atypical kinase …

The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …

Alternative splicing has emerged as an important target for molecular therapies. Splice-switching
oligonucleotides (SSOs) modulate alternative splicing by hybridizing to pre-mRNA …

Magnetic–plasmonic hybrid nanoparticles (MPHNs) have attracted great interest in cancer
theranostics. However, the relaxivity of the magnetic component is typically reduced by the …

Background. Phellodendri Cortex (PC) or Huang Bai. According to the scientific database of
China Plant Species and Chinese pharmacopeia 2015 edition, PC has two main species …

The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but
circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs …

Plasminogen activator inhibitor-2 (PAI-2), a member of the serpin gene family, is thought to
serve as a primary regulator of plasminogen activation in the extravascular compartment. …

A polymorphism in coagulation factor V, factor V Leiden (FVL), is the major known genetic
risk factor for thrombosis in humans. Approximately 10% of mutation carriers experience …