Importance To integrate the patient perspective into adverse event reporting, the National
Cancer Institute developed a patient-reported outcomes version of the Common Terminology …

Purpose There is growing interest to enhance symptom monitoring during routine cancer
care using patient-reported outcomes, but evidence of impact on clinical outcomes is limited. …

Measures of health-related quality of life (HRQOL) and other patient-reported outcomes
generate important data in cancer randomised trials to assist in assessing the risks and benefits …

Methods| The study was approved by the Memorial Sloan Kettering institutional review
board and written informed consent was obtained from participants. Consecutive patients …

Background A series of six manuscripts with an introduction appeared in the Mayo Clinic
Proceedings, based upon the collective effort of 30 individuals with an interest and expertise in …

This article deals with the incorporation of patient-reported outcomes (PROs) into clinical
trials and focuses on issues associated with the interpretation and reporting of PRO data. The …

The standard approach for documenting symptomatic adverse events (AEs) in cancer clinical
trials involves investigator reporting using the National Cancer Institute’s (NCI’s) Common …

Background The APOE ε4 allele is associated with the risk of late-onset Alzheimer's disease.
The age at which memory decline diverges among persons who are homozygous for the …

Purpose Myeloproliferative neoplasm (MPN) symptoms are troublesome to patients, and
alleviation of this burden represents a paramount treatment objective in the development of …

Methods| As described previously, 2 in this randomized trial, patients with advanced
nonprogressive stage IIA (TXN1) to IV lung cancer were randomly assigned within 3 months of …