Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Candidate gene and genome-wide association studies (GWAS) have identified genetic variants
that modulate risk for human disease; many of these associations require further study to …

Clinical data in electronic medical records (EMRs) are a potential source of longitudinal
clinical data for research. The Electronic Medical Records and Genomics Network (eMERGE) …

Objective: Genome-wide association studies (GWAS) require high specificity and large numbers
of subjects to identify genotype–phenotype correlations accurately. The aim of this study …

We repurposed existing genotypes in DNA biobanks across the Electronic Medical Records
and Genomics network to perform a genome-wide association study for primary …

With the completion of the Human Genome Project1 as well as recent advances in genomic
science and comparative biological studies, a new era of individualized medicine is evolving …

Background The appropriate dose of aspirin to lower the risk of death, myocardial infarction,
and stroke and to minimize major bleeding in patients with established atherosclerotic …

Background— ECG QRS duration, a measure of cardiac intraventricular conduction, varies
≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant …

Platelets are enucleated cell fragments derived from megakaryocytes that play key roles in
hemostasis and in the pathogenesis of atherothrombosis and cancer. Platelet traits are highly …

Objective To design and implement a tool that creates a secure, privacy preserving linkage of
electronic health record (EHR) data across multiple sites in a large metropolitan area in the …