User profiles for Abel Kho

Abel Kho

Professor, Northwestern University
Verified email at nm.org
Cited by 10471

Defining the role of common variation in the genomic and biological architecture of adult human height

…, J Jolley, T Juliusdottir, J Junttila, AN Kho… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

…, MA Basford, DS Carrell, PL Peissig, AN Kho… - Nature …, 2013 - nature.com
Candidate gene and genome-wide association studies (GWAS) have identified genetic variants
that modulate risk for human disease; many of these associations require further study to …

Validation of electronic medical record-based phenotyping algorithms: results and lessons learned from the eMERGE network

KM Newton, PL Peissig, AN Kho… - Journal of the …, 2013 - academic.oup.com
Background Genetic studies require precise phenotype definitions, but electronic medical
record (EMR) phenotype data are recorded inconsistently and in a variety of formats. Objective …

Design and implementation of a privacy preserving electronic health record linkage tool in Chicago

AN Kho, JP Cashy, KL Jackson, AR Pah… - Journal of the …, 2015 - academic.oup.com
Objective To design and implement a tool that creates a secure, privacy preserving linkage of
electronic health record (EHR) data across multiple sites in a large metropolitan area in the …

Primary care practices' abilities and challenges in using electronic health record data for quality improvement

…, ST Edwards, WY Wu, H Pham-Singer, AN Kho… - Health …, 2018 - healthaffairs.org
Federal value-based payment programs require primary care practices to conduct quality
improvement activities, informed by the electronic reports on clinical quality measures that their …

CAPriCORN: Chicago area patient-centered outcomes research network

AN Kho, DM Hynes, S Goel… - Journal of the …, 2014 - academic.oup.com
The Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN) represents
an unprecedented collaboration across diverse healthcare institutions including private, …

Electronic medical records for genetic research: results of the eMERGE consortium

AN Kho, JA Pacheco, PL Peissig… - Science translational …, 2011 - science.org
Clinical data in electronic medical records (EMRs) are a potential source of longitudinal
clinical data for research. The Electronic Medical Records and Genomics Network (eMERGE) …

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

AN Kho, MG Hayes, L Rasmussen-Torvik… - Journal of the …, 2012 - academic.oup.com
Objective: Genome-wide association studies (GWAS) require high specificity and large numbers
of subjects to identify genotype–phenotype correlations accurately. The aim of this study …

[PDF][PDF] Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome-and phenome-wide studies

…, L Rasmussen, X Wang, JA Pacheco, AN Kho… - The American Journal of …, 2011 - cell.com
We repurposed existing genotypes in DNA biobanks across the Electronic Medical Records
and Genomics network to perform a genome-wide association study for primary …

Electronic health records-driven phenotyping: challenges, recent advances, and perspectives

J Pathak, AN Kho, JC Denny - Journal of the American Medical …, 2013 - academic.oup.com
With the completion of the Human Genome Project1 as well as recent advances in genomic
science and comparative biological studies, a new era of individualized medicine is evolving …