Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs)
in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists …

Vegetation phenology is highly sensitive to climate change. Phenology also controls many
feedbacks of vegetation to the climate system by influencing the seasonality of albedo, …

Microorganisms are integral to the soil phosphorus (P) cycle and as such play an important
role in mediating the availability of P to plants. Understanding the microbial contribution to …

The resident prokaryotic microbiota of the metazoan gut elicits profound effects on the
growth and development of the intestine. However, the molecular mechanisms of symbiotic …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet
the functional contributions of these cells to tumorigenesis are poorly understood. Using a …

Mesenchymal stem cells have been recently described to localize to breast carcinomas,
where they integrate into the tumour-associated stroma. However, the involvement of …

Frontotemporal dementia (FTD) is the second most common cause of dementia in people
under the age of 65 years 1 . A large proportion of FTD patients (35–50%) have a family history …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

More than half of the solar energy absorbed by land surfaces is currently used to evaporate
water 1 . Climate change is expected to intensify the hydrological cycle 2 and to alter …