A telephone survey of Orleans Parish residents (25 to 65 years old; annual family incomes < $40,000) was conducted to explore cancer-related knowledge, beliefs, and practices. This paper presents descriptive information about knowledge and practices pertinent to early detection of cancer (breast self-examination, Pap smear, and mammogram) among women (N = 315). Income-related differences were observed. Women in the lower income group were less likely to routinely practice breast self-examination, and also less likely to have had a recent Pap smear or mammogram. Gaps in knowledge regarding the purpose of Pap smears and mammograms were noted. This sample of women reported their physicians are not routinely recommending Pap smears or mammograms. Findings highlight the need for community education programs to enhance awareness of the purpose and importance of cancer screening practices, particularly among the poor. In addition, all medical professionals who have contact with women need to reiterate the importance of regular participation in cancer-screening practices.