Abstract
A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anti-coagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.
MeSH terms
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Animals
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Anticoagulants / administration & dosage*
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Blood Coagulation Disorders / blood
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Blood Coagulation Disorders / diagnosis
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Blood Coagulation Disorders / drug therapy*
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Cattle
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Factor IX / biosynthesis
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Factor IXa
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Factor VII / analysis*
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Factor VII / biosynthesis
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Factor VII / physiology
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Factor VIIa
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Factor X / biosynthesis
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Factor X / physiology
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Factor Xa
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Half-Life
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Humans
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Kinetics
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Models, Biological
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Vitamin K / blood*
Substances
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Anticoagulants
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Vitamin K
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Factor VII
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Factor IX
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Factor X
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Factor VIIa
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Factor IXa
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Factor Xa