In a recent article, Eliason et al raise important questions regarding the need for nursing to focus greater attention on lesbian, gay, bisexual, and transgender (LGBT) issues. The present article discusses aspects of the profession's record on issues related to LGBT health and equality in the United States, focusing on civil rights, military discrimination, and human immunodeficiency virus/AIDS. It suggests an initial agenda focusing on public policy, nursing practice, education, and research. It then identifies potential organizational strategies for increasing the profession's visibility and consistency in addressing LGBT issues in the United States.