Resting heart rate, heart rate variability and blood pressure; the heart rate and blood pressure response to standing; and the heart rate response to Valsalva's manoeuvre, have been measured in a group of 12 patients with panic disorder and a group of 12 age- and sex-matched normal subjects. The patients had undergone treatment for their panic attacks with cognitive therapy; all had responded and all had been panic-free for a minimum of 4 months (mean 7.6 months). Mood ratings (BDI, BAI and SSAI) were comparable with established norms. The patients nevertheless had a raised resting systolic blood pressure, a reduced resting heart rate and an abnormal orthostatic response.