Gemfibrozil-induced myopathy

Arch Intern Med. 1991 Sep;151(9):1873-4.

Abstract

Drug-induced myopathy has been reported with use of lovastatin, nicotinic acid, and clofibrate. A particularly severe form, often accompanied by rhabdomyolysis, has been reported with the use of lovastatin and gemfibrozil; however, as far as we know, no case has been documented with use of gemfibrozil alone. Herein, we report the first case (to our knowledge of gemfibrozil-induced myopathy, confirmed by drug rechallenge.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Clofibrate / adverse effects
  • Drug Therapy, Combination
  • Gemfibrozil / adverse effects*
  • Gemfibrozil / therapeutic use
  • Humans
  • Hypertriglyceridemia / drug therapy
  • Lovastatin / adverse effects
  • Male
  • Middle Aged
  • Muscular Diseases / chemically induced*

Substances

  • Lovastatin
  • Clofibrate
  • Gemfibrozil