Spontaneous coronary dissection is an infrequent cause of acute myocardial infarction, and several cases have been presented during the peripartum period. We present a case of acute myocardial infarction resulting from spontaneous coronary artery dissection, in a 37-year-old woman during the postpartum period. Thrombolytic treatment was administered in the emergency room uneventfully but without symptom resolution. Diagnosis was subsequently established by coronary arteriography. The patient's in-hospital and long-term clinical course and prognosis are described and the potential pathogenetic mechanisms are discussed. Finally, the treatment options for this rare entity are presented.