Background: Elevations of coagulation factor VIII have recently been described in significant numbers of patients with venous thromboembolism (VTE) previously thought to have had an "idiopathic" event. Three patients from a family practice are presented with recurrent VTE and increased factor VIII levels.
Method: The case histories and results of laboratory tests were reviewed.
Results: The 3 patients had no other clear coagulopathy. In 2 of the 3, the increase was confirmed with a second reading.
Conclusions: Factor VIII assay should be considered in the work-up of idiopathic, recurrent VTE. Long-term anticoagulation may be appropriate in this setting.