Abstract
Background:
The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs.
Method:
All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed.
Results:
Forty-three (8.1%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis.
Conclusion:
Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.
MeSH terms
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Acute Disease
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Adult
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Antidepressive Agents / adverse effects*
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Antidepressive Agents / therapeutic use
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Antidepressive Agents, Tricyclic / adverse effects
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Antidepressive Agents, Tricyclic / therapeutic use
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Bipolar Disorder / chemically induced*
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Bipolar Disorder / diagnosis
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Bipolar Disorder / epidemiology
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Connecticut / epidemiology
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Female
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Hospitalization / statistics & numerical data*
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Humans
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Male
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Mental Disorders / drug therapy
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Mental Disorders / psychology
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Middle Aged
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Psychiatric Department, Hospital / statistics & numerical data
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Psychoses, Substance-Induced / diagnosis
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Psychoses, Substance-Induced / epidemiology
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Psychoses, Substance-Induced / etiology*
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Retrospective Studies
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Selective Serotonin Reuptake Inhibitors / adverse effects
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Selective Serotonin Reuptake Inhibitors / therapeutic use
Substances
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Antidepressive Agents
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Antidepressive Agents, Tricyclic
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Serotonin Uptake Inhibitors