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Exercise and Bone Mass in Adults

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Abstract

There is a substantial body of evidence indicating that exercise prior to the pubertal growth spurt stimulates bone growth and skeletal muscle hypertrophy to a greater degree than observed during growth in non-physically active children. Bone mass can be increased by some exercise programmes in adults and the elderly, and attenuate the losses in bone mass associated with aging. This review provides an overview of cross-sectional and longitudinal studies performed to date involving training and bone measurements. Cross-sectional studies show in general that exercise modalities requiring high forces and/or generating high impacts have the greatest osteogenic potential. Several training methods have been used to improve bone mineral density (BMD) and content in prospective studies. Not all exercise modalities have shown positive effects on bone mass. For example, unloaded exercise such as swimming has no impact on bone mass, while walking or running has limited positive effects.

It is not clear which training method is superior for bone stimulation in adults, although scientific evidence points to a combination of high-impact (i.e. jumping) and weight-lifting exercises. Exercise involving high impacts, even a relatively small amount, appears to be the most efficient for enhancing bone mass, except in postmenopausal women. Several types of resistance exercise have been tested also with positive results, especially when the intensity of the exercise is high and the speed of movement elevated. A handful of other studies have reported little or no effect on bone density. However, these results may be partially attributable to the study design, intensity and duration of the exercise protocol, and the bone density measurement techniques used. Studies performed in older adults show only mild increases, maintenance or just attenuation of BMD losses in postmenopausal women, but net changes in BMD relative to control subjects who are losing bone mass are beneficial in decreasing fracture risk. Older men have been less studied than women, and although it seems that men may respond better than their female counterparts, the experimental evidence for a dimorphism based on sex in the osteogenic response to exercise in the elderly is weak. A randomized longitudinal study of the effects of exercise on bone mass in elderly men and women is still lacking. It remains to be determined if elderly females need a different exercise protocol compared with men of similar age. Impact and resistance exercise should be advocated for the prevention of osteoporosis. For those with osteoporosis, weight-bearing exercise in general, and resistance exercise in particular, as tolerated, along with exercise targeted to improve balance, mobility and posture, should be recommended to reduce the likelihood of falling and its associated morbidity and mortality. Additional randomized controlled trials are needed to determine the most efficient training loads depending on age, sex, current bone mass and training history for improvement of bone mass.

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References

  1. Bouxsein ML, Karasik D. Bone geometry and skeletal fragility. Curr Osteoporos Rep 2006; 4 (2): 49–56

    PubMed  Google Scholar 

  2. Viguet-Carrin S, Garnero P, Delmas PD. The role of collagen in bone strength. Osteoporos Int 2006; 17 (3): 319–36

    PubMed  CAS  Google Scholar 

  3. Seeman E, Delmas PD. Bone quality: the material and structural basis of bone strength and fragility. N Engl J Med 2006; 354 (21): 2250–61

    PubMed  CAS  Google Scholar 

  4. Ottani V, Raspanti M, Ruggeri A. Collagen structure and functional implications. Micron 2001; 32 (3): 251–60

    PubMed  CAS  Google Scholar 

  5. Currey JD. Changes in the impact energy absorption of bone with age. J Biomech 1979; 12 (6): 459–69

    PubMed  CAS  Google Scholar 

  6. Currey JD. The effect of porosity and mineral content on the Young’s modulus of elasticity of compact bone. J Biomech 1988; 21 (2): 131–9

    PubMed  CAS  Google Scholar 

  7. Currey JD, Brear K, Zioupos P. The effects of ageing and changes in mineral content in degrading the toughness of human femora. J Biomech 1996; 29 (2): 257–60

    PubMed  CAS  Google Scholar 

  8. Bailey AJ, Wotton SF, Sims TJ, et al. Post-translational modifications in the collagen of human osteoporotic femoral head. Biochem Biophys Res Commun 1992; 185 (3): 801–5

    PubMed  CAS  Google Scholar 

  9. Boskey AL, Wright TM, Blank RD. Collagen and bone strength. J Bone Miner Res 1999; 14 (3): 330–5

    PubMed  CAS  Google Scholar 

  10. Wang X, Bank RA, TeKoppele JM, et al. The role of collagen in determining bone mechanical properties. J Orthop Res 2001; 19 (6): 1021–6

    PubMed  CAS  Google Scholar 

  11. Currey JD. The mechanical consequences of variation in the mineral content of bone. J Biomech 1969; 2 (1): 1–11

    PubMed  CAS  Google Scholar 

  12. Niyibizi C, Eyre DR. Structural characteristics of cross-linking sites in type V collagen of bone: chain specificities and heterotypic links to type I collagen. Eur J Biochem 1994; 224 (3): 943–50

    PubMed  CAS  Google Scholar 

  13. Eyre DR, Dickson IR, Van Ness K. Collagen cross-linking in human bone and articular cartilage: age-related changes in the content of mature hydroxypyridinium residues. Biochem J 1988; 252 (2): 495–500

    PubMed  CAS  Google Scholar 

  14. Fantner GE, Birkedal H, Kindt JH, et al. Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone. Bone 2004; 35 (5): 1013–22

    PubMed  CAS  Google Scholar 

  15. Banse X, Sims TJ, Bailey AJ. Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links. J Bone Miner Res 2002; 17 (9): 1621–8

    PubMed  CAS  Google Scholar 

  16. Fantner GE, Hassenkam T, Kindt JH, et al. Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nat Mater 2005; 4 (8): 612–6

    PubMed  CAS  Google Scholar 

  17. Hert J, Fiala P, Petrtyl M. Osteon orientation of the diaphysis of the long bones in man. Bone 1994; 15 (3): 269–77

    PubMed  CAS  Google Scholar 

  18. Martin RB, Boardman DL. The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech 1993; 26 (9): 1047–54

    PubMed  CAS  Google Scholar 

  19. Puustjarvi K, Nieminen J, Rasanen T, et al. Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training? J Bone Miner Res 1999; 14 (3): 321–9

    PubMed  CAS  Google Scholar 

  20. Harada S, Rodan GA. Control of osteoblast function and regulation of bone mass. Nature 2003; 423 (6937): 349–55

    PubMed  CAS  Google Scholar 

  21. Pavy-Le Traon A, Heer M, Narici MV, et al. From space to earth: advances in human physiology from 20 years of bed rest studies (1986–2006). Eur J Appl Physiol 2007; 101 (2): 143–94

    PubMed  CAS  Google Scholar 

  22. Chilibeck PD, Sale DG, Webber CE. Exercise and bone mineral density. Sports Med 1995; 19 (2): 103–22

    PubMed  CAS  Google Scholar 

  23. Frost HM. Bone’s mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 2003; 275 (2): 1081–101

    PubMed  Google Scholar 

  24. Rittweger J. What is new in neuro-musculoskeletal interactions: mechanotransduction, microdamage and repair? J Musculoskel Neuron Interact 2007; 7 (2): 191–3

    CAS  Google Scholar 

  25. Rosen CJ. Bone remodeling, energy metabolism, and the molecular clock. Cell Metab 2008; 7 (1): 7–10

    PubMed  CAS  Google Scholar 

  26. Lee KC, Lanyon LE. Mechanical loading influences bone mass through estrogen receptor alpha. Exerc Sport Sci Rev 2004; 32 (2): 64–8

    PubMed  Google Scholar 

  27. Skerry TM. One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture. J Musculoskel Neuron Interact 2006; 6 (2): 122–7

    CAS  Google Scholar 

  28. Scott A, Khan KM, Duronio V, et al. Mechanotransduction in human bone: in vitro cellular physiology that underpins bone changes with exercise. Sports Med 2008; 38 (2): 139–60

    PubMed  Google Scholar 

  29. Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene 2006; 367: 1–16

    PubMed  CAS  Google Scholar 

  30. Saxon LK, Lanyon LE. Assessment of the in vivo adaptive response to mechanical loading. Method Molec Biol 2008; 455: 307–22

    Google Scholar 

  31. Frost HM. Bone “mass” and the “mechanostat”: a proposal. Anat Rec 1987; 219 (1): 1–9

    PubMed  CAS  Google Scholar 

  32. Frost HM. Wolff’s law: an ‘MGS’ derivation of gamma in the Three-Way Rule for mechanically controlled lamellar bone modeling drifts. Bone Miner 1993; 22 (2): 117–27

    PubMed  CAS  Google Scholar 

  33. Bailey CA, Brooke-Wavell K. Exercise for optimising peak bone mass in women. Proc Nutr Soc 2008; 67 (1): 9–18

    PubMed  CAS  Google Scholar 

  34. Shaw J. Exercise for skeletal health and osteoporosis prevention: ACSM’s resource manual for guidelines for exercise testing and prescription. Philadelphia (PA): Lippincott Williams & Wilkins, 1998: 288–93

    Google Scholar 

  35. Frost HM. Skeletal structural adaptations to mechanical usage (SATMU): 1, redefining Wolff’s law–the bone modeling problem. Anat Rec 1990; 226 (4): 403–13

    PubMed  CAS  Google Scholar 

  36. Burr DB, Forwood MR, Fyhrie DP, et al. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 1997; 12 (1): 6–15

    PubMed  CAS  Google Scholar 

  37. Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 1984; 66 (3): 397–402

    PubMed  CAS  Google Scholar 

  38. Rubin C, Turner AS, Bain S, et al. Anabolism: low mechanical signals strengthen long bones. Nature 2001; 412 (6847): 603–4

    PubMed  CAS  Google Scholar 

  39. Rubin C, Turner AS, Muller R, et al. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res 2002; 17 (2): 349–57

    PubMed  Google Scholar 

  40. Borer KT. Physical activity in the prevention and amelioration of osteoporosis in women: interaction of mechanical, hormonal and dietary factors. Sports Med 2005; 35 (9): 779–830

    PubMed  Google Scholar 

  41. Nordström A, Karlsson C, Nyquist F, et al. Bone loss and fracture risk after reduced physical activity. J Bone Miner Res 2005; 20 (2): 202–7

    PubMed  Google Scholar 

  42. WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser 1994; 843: 1–129

    Google Scholar 

  43. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women: Study of Osteoporotic Fractures Research Group. N Engl J Med 1995; 332 (12): 767–73

    PubMed  CAS  Google Scholar 

  44. Kanis JA, Melton 3rd LJ, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res 1994; 9 (8): 1137–41

    PubMed  CAS  Google Scholar 

  45. Mein AL, Briffa NK, Dhaliwal SS, et al. Lifestyle influences on 9-year changes in BMD in young women. J Bone Miner Res 2004; 19 (7): 1092–8

    PubMed  Google Scholar 

  46. Vicente-Rodriguez G. How does exercise affect bone development during growth? Sports Med 2006; 36 (7): 561–9

    PubMed  Google Scholar 

  47. Vicente-Rodriguez G, Jimenez-Ramirez J, Ara I, et al. Enhanced bone mass and physical fitness in prepubescent footballers. Bone 2003; 33 (5): 853–9

    PubMed  CAS  Google Scholar 

  48. Vicente-Rodriguez G, Dorado C, Perez-Gomez J, et al. Enhanced bone mass and physical fitness in young female handball players. Bone 2004; 35 (5): 1208–15

    PubMed  CAS  Google Scholar 

  49. Vicente-Rodriguez G, Dorado C, Ara I, et al. Artistic versus rhythmic gymnastics: effects on bone and muscle mass in young girls. Int J Sports Med 2007; 28 (5): 386–93

    PubMed  CAS  Google Scholar 

  50. McVeigh JA, Norris SA, Pettifor JM. Bone mass accretion rates in pre- and early-pubertal South African black and white children in relation to habitual physical activity and dietary calcium intakes. Acta Paediatr 2007; 96 (6): 874–80

    PubMed  CAS  Google Scholar 

  51. Vicente-Rodriguez G, Ara I, Perez-Gomez J, et al. High femoral bone mineral density accretion in prepubertal soccer players. Med Sci Sports Exerc 2004; 36 (10): 1789–95

    PubMed  Google Scholar 

  52. Wang Q, Alen M, Nicholson P, et al. Weight-bearing, muscle loading and bone mineral accrual in pubertal girls: a 2-year longitudinal study. Bone 2007; 40 (5): 1196–202

    PubMed  Google Scholar 

  53. Bradney M, Pearce G, Naughton G, et al. Moderate exercise during growth in prepubertal boys: changes in bone mass, size, volumetric density, and bone strength: a controlled prospective study. J Bone Miner Res 1998; 13 (12): 1814–21

    PubMed  CAS  Google Scholar 

  54. Bass SL. The prepubertal years: a uniquely opportune stage of growth when the skeleton is most responsive to exercise? Sports Med 2000; 30 (2): 73–8

    PubMed  CAS  Google Scholar 

  55. Bailey DA, McKay HA, Mirwald RL, et al. A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children: the university of Saskatchewan bone mineral accrual study. J Bone Miner Res 1999; 14 (10): 1672–9

    PubMed  CAS  Google Scholar 

  56. Greene DA, Naughton GA. Adaptive skeletal responses to mechanical loading during adolescence. Sports Med 2006; 36 (9): 723–32

    PubMed  Google Scholar 

  57. Bass SL, Saxon L, Daly RM, et al. The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players. J Bone Miner Res 2002; 17 (12): 2274–80

    PubMed  CAS  Google Scholar 

  58. Seeman E. An exercise in geometry. J Bone Miner Res 2002; 17 (3): 373–80

    PubMed  Google Scholar 

  59. Kannus P, Haapasalo H, Sankelo M, et al. Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Ann Intern Med 1995; 123 (1): 27–31

    PubMed  CAS  Google Scholar 

  60. Heinonen A, Sievanen H, Kannus P, et al. High-impact exercise and bones of growing girls: a 9-month controlled trial. Osteoporos Int 2000; 11 (12): 1010–7

    PubMed  CAS  Google Scholar 

  61. Manias K, McCabe D, Bishop N. Fractures and recurrent fractures in children; varying effects of environmental factors as well as bone size and mass. Bone 2006; 39 (3): 652–7

    PubMed  Google Scholar 

  62. Laing EM, Wilson AR, Modlesky CM, et al. Initial years of recreational artistic gymnastics training improves lumbar spine bone mineral accrual in 4- to 8-year-old females. J Bone Miner Res 2005; 20 (3): 509–19

    PubMed  Google Scholar 

  63. Lanyon LE. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone 1996; 18 (1 Suppl.): 37S–43S

    PubMed  CAS  Google Scholar 

  64. Martyn-St James M, Carroll S. Progressive high-intensity resistance training and bone mineral density changes among premenopausal women: evidence of discordant site-specific skeletal effects. Sports Med 2006; 36 (8): 683–704

    PubMed  Google Scholar 

  65. Forwood MR, Turner CH. The response of rat tibiae to incremental bouts of mechanical loading: a quantum concept for bone formation. Bone 1994; 15 (6): 603–9

    PubMed  CAS  Google Scholar 

  66. Pazzaglia UE, Andrini L, Di Nucci A. The effects of mechanical forces on bones and joints: experimental study on the rat tail. J Bone Joint Surg Br 1997; 79 (6): 1024–30

    PubMed  CAS  Google Scholar 

  67. Robling AG, Duijvelaar KM, Geevers JV, et al. Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force. Bone 2001; 29 (2): 105–13

    PubMed  CAS  Google Scholar 

  68. Ehrlich PJ, Lanyon LE. Mechanical strain and bone cell function: a review. Osteoporos Int 2002; 13 (9): 688–700

    PubMed  CAS  Google Scholar 

  69. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000; 80 (3): 1055–81

    PubMed  CAS  Google Scholar 

  70. Van Hall G, Jensen-Urstad M, Rosdahl H, et al. Leg and arm lactate and substrate kinetics during exercise. Am J Physiol Endocrinol Metab 2003; 284 (1): E193–205

    PubMed  Google Scholar 

  71. Mastorakos G, Pavlatou M. Exercise as a stress model and the interplay between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axes. Horm Metab Res 2005; 37 (9): 577–84

    PubMed  CAS  Google Scholar 

  72. Calbet JA, Lundby C, Sander M, et al. Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans. Am J Physiol Regul Integr Comp Physiol 2006; 291 (2): R447–53

    PubMed  CAS  Google Scholar 

  73. Ara I, Perez-Gomez J, Vicente-Rodriguez G, et al. Serum free testosterone, leptin and soluble leptin receptor changes in a 6-week strength-training programme. Br J Nutr 2006; 96 (6): 1053–9

    PubMed  CAS  Google Scholar 

  74. Frost HM, Jee WS. On the rat model of human osteopenias and osteoporoses. Bone Miner 1992; 18 (3): 227–36

    PubMed  CAS  Google Scholar 

  75. Bourrin S, Palle S, Pupier R, et al. Effect of physical training on bone adaptation in three zones of the rat tibia. J Bone Miner Res 1995; 10 (11): 1745–52

    PubMed  CAS  Google Scholar 

  76. Yeh JK, Liu CC, Aloia JF. Effects of exercise and immobilization on bone formation and resorption in young rats. Am J Physiol 1993; 264 (2 Pt 1): E182–9

    PubMed  CAS  Google Scholar 

  77. Hagihara Y, Fukuda S, Goto S, et al. How many days per week should rats undergo running exercise to increase BMD? J Bone Miner Metab 2005; 23 (4): 289–94

    PubMed  Google Scholar 

  78. Barengolts EI, Curry DJ, Bapna MS, et al. Effects of endurance exercise on bone mass and mechanical properties in intact and ovariectomized rats. J Bone Miner Res 1993; 8 (8): 937–42

    PubMed  CAS  Google Scholar 

  79. Horcajada M, Coxam V, Davicco M, et al. Influence of treadmill running on femoral bone in young orchidectomized rats. J Appl Physiol 1997; 83 (1): 129–33

    PubMed  CAS  Google Scholar 

  80. van der Wiel HE, Lips P, Graafmans WC, et al. Additional weight-bearing during exercise is more important than duration of exercise for anabolic stimulus of bone: a study of running exercise in female rats. Bone 1995; 16 (1): 73–80

    PubMed  Google Scholar 

  81. Bourrin S, Genty C, Palle S, et al. Adverse effects of strenuous exercise: a densitometric and histomorphometric study in the rat. J Appl Physiol 1994; 76 (5): 1999–2005

    PubMed  CAS  Google Scholar 

  82. Iwamoto J, Takeda T, Sato Y. Effect of treadmill exercise on bone mass in female rats. Exp Anim 2005; 54 (1): 1–6

    PubMed  CAS  Google Scholar 

  83. Wronski TJ, Yen CF. The ovariectomized rat as an animal-model for postmenopausal bone loss. Cell Mater Suppl 1991; 1: 69–74

    Google Scholar 

  84. Jarvinen TL, Kannus P, Pajamaki I, et al. Estrogen deposits extra mineral into bones of female rats in puberty, but simultaneously seems to suppress the responsiveness of female skeleton to mechanical loading. Bone 2003; 32 (6): 642–51

    PubMed  CAS  Google Scholar 

  85. Sanchis-Moysi J, Dorado C, Vicente-Rodriguez G, et al. Inter-arm asymmetry in bone mineral content and bone area in postmenopausal recreational tennis players. Maturitas 2004; 48 (3): 289–98

    PubMed  CAS  Google Scholar 

  86. Calbet JA, Dorado C, Diaz-Herrera P, et al. High femoral bone mineral content and density in male football (soccer) players. Med Sci Sports Exerc 2001; 33 (10): 1682–7

    PubMed  CAS  Google Scholar 

  87. Morel J, Combe B, Francisco J, et al. Bone mineral density of 704 amateur sportsmen involved in different physical activities. Osteoporos Int 2001; 12 (2): 152–7

    PubMed  CAS  Google Scholar 

  88. Calbet JA, Moysi JS, Dorado C, et al. Bone mineral content and density in professional tennis players. Calcif Tissue Int 1998; 62 (6): 491–6

    PubMed  CAS  Google Scholar 

  89. Wittich A, Mautalen CA, Oliveri MB, et al. Professional football (soccer) players have a markedly greater skeletal mineral content, density and size than age- and BMI-matched controls. Calcif Tissue Int 1998; 63 (2): 112–7

    PubMed  CAS  Google Scholar 

  90. Egan E, Reilly T, Giacomoni M, et al. Bone mineral density among female sports participants. Bone 2006; 38 (2): 227–33

    PubMed  Google Scholar 

  91. Nichols JF, Rauh MJ, Barrack MT, et al. Bone mineral density in female high school athletes: interactions of menstrual function and type of mechanical loading. Bone 2007; 41 (3): 371–7

    PubMed  Google Scholar 

  92. Alfredson H, Nordström P, Lorentzon R. Total and regional bone mass in female soccer players. Calcif Tissue Int 1996; 59 (6): 438–42

    PubMed  CAS  Google Scholar 

  93. Ducher G, Prouteau S, Courteix D, et al. Cortical and trabecular bone at the forearm show different adaptation patterns in response to tennis playing. J Clin Densitom 2004; 7 (4): 399–405

    PubMed  Google Scholar 

  94. Karlsson MK. Skeletal effects of exercise in men. Calcif Tissue Int 2001; 69 (4): 196–9

    PubMed  CAS  Google Scholar 

  95. Layne JE, Nelson ME. The effects of progressive resistance training on bone density: a review. Med Sci Sports Exerc 1999; 31 (1): 25–30

    PubMed  CAS  Google Scholar 

  96. Nichols DL, Sanborn CF, Essery EV. Bone density and young athletic women: an update. Sports Med 2007; 37 (11): 1001–14

    PubMed  Google Scholar 

  97. Karlsson M. Has exercise an antifracture efficacy in women? Scand J Med Sci Sports 2004; 14 (1): 2–15

    PubMed  Google Scholar 

  98. Daly RM, Rich PA, Klein R, et al. Effects of high-impact exercise on ultrasonic and biochemical indices of skeletal status: a prospective study in young male gymnasts. J Bone Miner Res 1999; 14 (7): 1222–30

    PubMed  CAS  Google Scholar 

  99. Taaffe DR, Snow-Harter C, Connolly DA, et al. Differential effects of swimming versus weight-bearing activity on bone mineral status of eumenorrheic athletes. J Bone Miner Res 1995; 10 (4): 586–93

    PubMed  CAS  Google Scholar 

  100. Hawkey A. The importance of exercising in space. Interdiscip Sci Rev 2003; 28 (2): 130–8

    PubMed  Google Scholar 

  101. Perez-Gomez J, Olmedillas H, Delgado-Guerra S, et al. Effects of weight lifting training combined with plyometric exercises on physical fitness, body composition, and knee extension velocity during kicking in football. Appl Physiol Nutr Metab 2008; 33 (3): 501–10

    PubMed  CAS  Google Scholar 

  102. Kellis E, Katis A, Vrabas IS. Effects of an intermittent exercise fatigue protocol on biomechanics of soccer kick performance. Scand J Med Sci Sports 2006; 16 (5): 334–44

    PubMed  CAS  Google Scholar 

  103. Hetland ML, Haarbo J, Christiansen C. Low bone mass and high bone turnover in male long distance runners. J Clin Endocrinol Metab 1993; 77 (3): 770–5

    PubMed  CAS  Google Scholar 

  104. Kannus P, Haapasalo H, Sievanen H, et al. The site-specific effects of long-term unilateral activity on bone mineral density and content. Bone 1994; 15 (3): 279–84

    PubMed  CAS  Google Scholar 

  105. Haapasalo H, Kannus P, Sievanen H, et al. Long-term unilateral loading and bone mineral density and content in female squash players. Calcif Tissue Int 1994; 54 (4): 249–55

    PubMed  CAS  Google Scholar 

  106. Ducher G, Tournaire N, Meddahi-Pelle A, et al. Short-term and long-term site-specific effects of tennis playing on trabecular and cortical bone at the distal radius. J Bone Miner Metab 2006; 24 (6): 484–90

    PubMed  Google Scholar 

  107. Vicente-Rodriguez G. How does exercise affect bone development during growth? Sports Med 2006; 36 (7): 561–9

    PubMed  Google Scholar 

  108. Calbet JA, Dorado C, Diaz-Herrera P, et al. High femoral bone mineral content and density in male football (soccer) players. Med Sci Sports Exerc 2001; 33 (10): 1682–7

    PubMed  CAS  Google Scholar 

  109. Egan E, Reilly T, Giacomoni M, et al. Bone mineral density among female sports participants. Bone 2006; 38 (2): 227–33

    PubMed  Google Scholar 

  110. Ng MY, Sham PC, Paterson AD, et al. Effect of environmental factors and gender on the heritability of bone mineral density and bone size. Ann Hum Genet 2006; 70 (Pt 4): 428–38

    PubMed  CAS  Google Scholar 

  111. Kemper HC, Post GB, Twisk JW, et al. Lifestyle and obesity in adolescence and young adulthood: results from the Amsterdam Growth And Health Longitudinal Study (AGAHLS). Int J Obes Relat Metab Disord 1999; 23 Suppl. 3: S34–40

    PubMed  Google Scholar 

  112. Armstrong N, Welsman JR. The physical activity patterns of European youth with reference to methods of assessment. Sports Med 2006; 36 (12): 1067–86

    PubMed  Google Scholar 

  113. Tanner JM. Principles of growth standards. Acta Paediatr Scand 1990; 79 (10): 963–7

    PubMed  CAS  Google Scholar 

  114. Friedlander AL, Genant HK, Sadowsky S, et al. A two-year program of aerobics and weight training enhances bone mineral density of young women. J Bone Miner Res 1995; 10 (4): 574–85

    PubMed  CAS  Google Scholar 

  115. Schroeder ET, Hawkins SA, Jaque SV. Musculoskeletal adaptations to 16 weeks of eccentric progressive resistance training in young women. J Strength Cond Res 2004; 18 (2): 227–35

    PubMed  Google Scholar 

  116. Hawkins SA, Schroeder ET, Wiswell RA, et al. Eccentric muscle action increases site-specific osteogenic response. Med Sci Sports Exerc 1999; 31 (9): 1287–92

    PubMed  CAS  Google Scholar 

  117. Nickols-Richardson SM, Miller LE, Wootten DF, et al. Concentric and eccentric isokinetic resistance training similarly increases muscular strength, fat-free soft tissue mass, and specific bone mineral measurements in young women. Osteoporos Int 2007; 18 (6): 789–96

    PubMed  CAS  Google Scholar 

  118. Kato T, Terashima T, Yamashita T, et al. Effect of low-repetition jump training on bone mineral density in young women. J Appl Physiol 2006; 100 (3): 839–43

    PubMed  Google Scholar 

  119. Bassey EJ, Ramsdale SJ. Increase in femoral bone density in young women following high-impact exercise. Osteoporos Int 1994; 4 (2): 72–5

    PubMed  CAS  Google Scholar 

  120. Sinaki M, Wahner HW, Bergstralh EJ, et al. Three-year controlled, randomized trial of the effect of dose-specified loading and strengthening exercises on bone mineral density of spine and femur in nonathletic, physically active women. Bone 1996; 19 (3): 233–44

    PubMed  CAS  Google Scholar 

  121. Chilibeck PD, Calder A, Sale DG, et al. Twenty weeks of weight training increases lean tissue mass but not bone mineral mass or density in healthy, active young women. Can J Physiol Pharmacol 1996; 74 (10): 1180–5

    PubMed  CAS  Google Scholar 

  122. Nindl BC, Harman EA, Marx JO, et al. Regional body composition changes in women after 6 months of periodized physical training. J Appl Physiol 2000; 88 (6): 2251–9

    PubMed  CAS  Google Scholar 

  123. Lohman T, Going S, Pamenter R, et al. Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 1995; 10 (7): 1015–24

    PubMed  CAS  Google Scholar 

  124. Vainionpää A, Korpelainen R, Leppaluoto J, et al. Effects of high-impact exercise on bone mineral density: a randomized controlled trial in premenopausal women. Osteoporos Int 2005; 16 (2): 191–7

    PubMed  Google Scholar 

  125. Winters-Stone KM, Snow CM. Site-specific response of bone to exercise in premenopausal women. Bone 2006; 39 (6): 1203–9

    PubMed  Google Scholar 

  126. Heinonen A, Kannus P, Sievanen H, et al. Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures. Lancet 1996; 348 (9038): 1343–7

    PubMed  CAS  Google Scholar 

  127. Kohrt WM, Bloomfield SA, Little KD, et al. American College of Sports Medicine Position Stand: physical activity and bone health. Med Sci Sports Exerc 2004; 36 (11): 1985–96

    PubMed  Google Scholar 

  128. Deschenes MR, Kraemer WJ. Performance and physiologic adaptations to resistance training. Am J Phys Med Rehabil 2002; 81 (11 Suppl.): S3–16

    PubMed  Google Scholar 

  129. Kraemer WJ, Ratamess NA. Fundamentals of resistance training: progression and exercise prescription. Med Sci Sports Exerc 2004; 36 (4): 674–88

    PubMed  Google Scholar 

  130. Kraemer WJ, Mazzetti SA, Nindl BC, et al. Effect of resistance training on women’s strength/power and occupational performances. Med Sci Sports Exerc 2001; 33 (6): 1011–25

    PubMed  CAS  Google Scholar 

  131. Kraemer WJ, Nindl BC, Ratamess NA, et al. Changes in muscle hypertrophy in women with periodized resistance training. Med Sci Sports Exerc 2004; 36 (4): 697–708

    PubMed  Google Scholar 

  132. Uusi-Rasi K, Sievanen H, Pasanen M, et al. Association of physical activity and calcium intake with the maintenance of bone mass in premenopausal women. Osteoporos Int 2002; 13 (3): 211–7

    PubMed  CAS  Google Scholar 

  133. Snow-Harter C, Bouxsein ML, Lewis BT, et al. Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res 1992; 7 (7): 761–9

    PubMed  CAS  Google Scholar 

  134. Mayhew TP, Rothstein JM, Finucane SD, et al. Muscular adaptation to concentric and eccentric exercise at equal power levels. Med Sci Sports Exerc 1995; 27 (6): 868–73

    PubMed  CAS  Google Scholar 

  135. Gilsanz V, Wren TA, Sanchez M, et al. Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. J Bone Miner Res 2006; 21 (9): 1464–74

    PubMed  Google Scholar 

  136. Fujimura R, Ashizawa N, Watanabe M, et al. Effect of resistance exercise training on bone formation and resorption in young male subjects assessed by biomarkers of bone metabolism. J Bone Miner Res 1997; 12 (4): 656–62

    PubMed  CAS  Google Scholar 

  137. Hartman JW, Tang JE, Wilkinson SB, et al. Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters. Am J Clin Nutr 2007; 86 (2): 373–81

    PubMed  CAS  Google Scholar 

  138. Ballard TL, Specker BL, Binkley TL, et al. Effect of protein supplementation during a 6-month strength and conditioning program on areal and volumetric bone parameters. Bone 2006; 38 (6): 898–904

    PubMed  CAS  Google Scholar 

  139. Ryan AS, Ivey FM, Hurlbut DE, et al. Regional bone mineral density after resistive training in young and older men and women. Scand J Med Sci Sports 2004; 14 (1): 16–23

    PubMed  Google Scholar 

  140. Mullins NM, Sinning WE. Effects of resistance training and protein supplementation on bone turnover in young adult women. Nutr Metab (Lond) 2005; 2: 19

    Google Scholar 

  141. Torvinen S, Kannus P, Sievanen H, et al. Effect of 8-month vertical whole body vibration on bone, muscle performance, and body balance: a randomized controlled study. J Bone Miner Res 2003; 18 (5): 876–84

    PubMed  Google Scholar 

  142. Beck BR, Kent K, Holloway L, et al. Novel, high-frequency, low-strain mechanical loading for pre-menopausal women with low bone mass: early findings. J Bone Mineral Metab 2006; 24 (6): 505–7

    Google Scholar 

  143. Menkes A, Mazel S, Redmond RA, et al. Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol 1993; 74 (5): 2478–84

    PubMed  CAS  Google Scholar 

  144. Huuskonen J, Vaisanen SB, Kroger H, et al. Regular physical exercise and bone mineral density: a four-year controlled randomized trial in middle-aged men — the DNASCO study. Osteoporos Int 2001; 12 (5): 349–55

    PubMed  CAS  Google Scholar 

  145. Stewart KJ, Bacher AC, Hees PS, et al. Exercise effects on bone mineral density relationships to changes in fitness and fatness. Am J Prev Med 2005; 28 (5): 453–60

    PubMed  Google Scholar 

  146. Madeo B, Zirilli L, Caffagni G, et al. The osteoporotic male: overlooked and undermanaged? Clin Interv Aging 2007; 2 (3): 305–12

    PubMed  Google Scholar 

  147. Hui SL, Slemenda CW, Johnston Jr CC, et al. The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int 1990; 1 (1): 30–4

    PubMed  CAS  Google Scholar 

  148. Jones HH, Priest JD, Hayes WC, et al. Humeral hypertrophy in response to exercise. J Bone Joint Surg Am 1977; 59 (2): 204–8

    PubMed  CAS  Google Scholar 

  149. Province MA, Hadley EC, Hornbrook MC, et al. The effects of exercise on falls in elderly patients: a preplanned meta-analysis of the FICSIT Trials. Frailty and injuries: cooperative studies of intervention techniques. JAMA 1995; 273 (17): 1341–7

    PubMed  CAS  Google Scholar 

  150. Paganini-Hill A, Chao A, Ross RK, et al. Exercise and other factors in the prevention of hip fracture: the Leisure World study. Epidemiology 1991; 2 (1): 16–25

    PubMed  CAS  Google Scholar 

  151. Wyshak G, Frisch RE, Albright TE, et al. Bone fractures among former college athletes compared with nonathletes in the menopausal and postmenopausal years. Obstet Gynecol 1987; 69 (1): 121–6

    PubMed  CAS  Google Scholar 

  152. Nelson ME, Fiatarone MA, Morganti CM, et al. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures: a randomized controlled trial. JAMA 1994; 272 (24): 1909–14

    PubMed  CAS  Google Scholar 

  153. Kerr D, Morton A, Dick I, et al. Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent. J Bone Miner Res 1996; 11 (2): 218–25

    PubMed  CAS  Google Scholar 

  154. Kohrt WM, Snead DB, Slatopolsky E, et al. Additive effects of weight-bearing exercise and estrogen on bone mineral density in older women. J Bone Miner Res 1995; 10 (9): 1303–11

    PubMed  CAS  Google Scholar 

  155. Stengel SV, Kemmler W, Pintag R, et al. Power training is more effective than strength training for maintaining bone mineral density in postmenopausal women. J Appl Physiol 2005; 99 (1): 181–8

    PubMed  CAS  Google Scholar 

  156. Chien MY, Wu YT, Hsu AT, et al. Efficacy of a 24-week aerobic exercise program for osteopenic postmenopausal women. Calcif Tissue Int 2000; 67 (6): 443–8

    PubMed  CAS  Google Scholar 

  157. Kohrt WM, Ehsani AA, Birge Jr SJ, et al. Effects of exercise involving predominantly either joint-reaction or ground-reaction forces on bone mineral density in older women. J Bone Miner Res 1997; 12 (8): 1253–61

    PubMed  CAS  Google Scholar 

  158. Verschueren SM, Roelants M, Delecluse C, et al. Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. J Bone Miner Res 2004; 19 (3): 352–9

    PubMed  Google Scholar 

  159. Pruitt LA, Jackson RD, Bartels RL, et al. Weight-training effects on bone mineral density in early postmenopausal women. J Bone Miner Res 1992; 7 (2): 179–85

    PubMed  CAS  Google Scholar 

  160. Maddalozzo GF, Snow CM. High intensity resistance training: effects on bone in older men and women. Calcif Tissue Int 2000; 66 (6): 399–404

    PubMed  CAS  Google Scholar 

  161. Ryan AS, Treuth MS, Rubin MA, et al. Effects of strength training on bone mineral density: hormonal and bone turnover relationships. J Appl Physiol 1994; 77 (4): 1678–84

    PubMed  CAS  Google Scholar 

  162. Ryan AS, Treuth MS, Hunter GR, et al. Resistive training maintains bone mineral density in postmenopausal women. Calcif Tissue Int 1998; 62 (4): 295–9

    PubMed  CAS  Google Scholar 

  163. Bassey EJ, Rothwell MC, Littlewood JJ, et al. Pre- and postmenopausal women have different bone mineral density responses to the same high-impact exercise. J Bone Miner Res 1998; 13 (12): 1805–13

    PubMed  CAS  Google Scholar 

  164. Sugiyama T, Yamaguchi A, Kawai S. Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the “mechanostat” theory. J Bone Miner Metab 2002; 20 (4): 196–200

    PubMed  Google Scholar 

  165. Palombaro KM. Effects of walking-only interventions on bone mineral density at various skeletal sites: a metaanalysis. J Geriatr Phys Ther 2005; 28 (3): 102–7

    PubMed  Google Scholar 

  166. Bergmann G, Graichen F, Rohlmann A. Hip joint loading during walking and running, measured in two patients. J Biomech 1993; 26 (8): 969–90

    PubMed  CAS  Google Scholar 

  167. Gusi N, Raimundo A, Leal A. Low-frequency vibratory exercise reduces the risk of bone fracture more than walking: a randomized controlled trial. BMC Musculoskel Disord 2006; 7: 92

    Google Scholar 

  168. Rubin C, Recker R, Cullen D, et al. Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J Bone Miner Res 2004; 19 (3): 343–51

    PubMed  Google Scholar 

  169. Zehnacker CH, Bemis-Dougherty A. Effect of weighted exercises on bone mineral density in post menopausal women: a systematic review. J Geriatr Phys Ther 2007; 30 (2): 79–88

    PubMed  Google Scholar 

  170. Englund U, Littbrand H, Sondell A, et al. The beneficial effects of exercise on BMD are lost after cessation: a 5-year follow-up in older post-menopausal women. Scand J Med Sci Sports. Epub 2008 May 22

  171. Mackey DC, Lui LY, Cawthon PM, et al. High-trauma fractures and low bone mineral density in older women and men. JAMA 2007; 298 (20): 2381–8

    PubMed  CAS  Google Scholar 

  172. Frost HM. Some effects of basic multicellular unit-based remodelling on photon absorptiometry of trabecular bone. Bone Miner 1989; 7 (1): 47–65

    PubMed  CAS  Google Scholar 

  173. Forwood MR, Burr DB. Physical activity and bone mass: exercises in futility? Bone Miner 1993; 21 (2): 89–112

    PubMed  CAS  Google Scholar 

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Acknowledgements

The study was supported financially by Ministerio de Educación y Ciencia (DEP2006-56076-C06-04/ACTI). Consejería de Educación, Cultura y Deportes del Gobierno de Canarias (2006/179 0001 and FEDER). Borja Guerra is a fellow of the ‘Recursos Humanos y Difusión de la Investigación’ Program (ISCIII, MSC, Spain). The authors thank José Navarro de Tuero for his excellent technical assistance. The specialized advice from Tony Webster in editing the English version of the manuscript is also acknowledged. The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain

    Amelia Guadalupe-Grau, Teresa Fuentes, Borja Guerra &  Jose A. L. Calbet

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  1. Amelia Guadalupe-Grau
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  2. Teresa Fuentes
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Correspondence to Jose A. L. Calbet.

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Guadalupe-Grau, A., Fuentes, T., Guerra, B. et al. Exercise and Bone Mass in Adults. Sports Med 39, 439–468 (2009). https://doi.org/10.2165/00007256-200939060-00002

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