Estrogenic and Anti-androgenic Activity of Nitrophenols in Diesel Exhaust Particles (DEP)

Shinji Taneda; Yoki Mori; Kazuyuki Kamata; Hideyuki Hayashi; Chie Furuta; Chunmei Li; Koh-ichi Seki; Akiyo Sakushima; Shin Yoshino; Kouya Yamaki; Gen Watanabe; Kazuyoshi Taya; Akira K. Suzuki

doi:10.1248/bpb.27.835

Regular Articles

Estrogenic and Anti-androgenic Activity of Nitrophenols in Diesel Exhaust Particles (DEP)

Shinji Taneda, Yoki Mori, Kazuyuki Kamata, Hideyuki Hayashi, Chie Furuta, Chunmei Li, Koh-ichi Seki, Akiyo Sakushima, Shin Yoshino, Kouya Yamaki, Gen Watanabe, Kazuyoshi Taya, Akira K. Suzuki

Author information

Shinji Taneda
PM2.5/DEP Research Project, National Institute for Environmental Studies, Japan
Yoki Mori
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
Kazuyuki Kamata
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
Hideyuki Hayashi
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
Chie Furuta
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Chunmei Li
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University
Koh-ichi Seki
Central Institute of Isotope Science, Graduate School of Medicine, Hokkaido University
Akiyo Sakushima
Faculty of Pharmaceutical Sciences, Kyushu University of Health and Welfare
Shin Yoshino
Kobe Pharmaceutical University
Kouya Yamaki
Kobe Pharmaceutical University
Gen Watanabe
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Kazuyoshi Taya
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
Department of Basic Veterinary Sciences, The United Graduate School of Veterinary Sciences, Gifu University
Akira K. Suzuki
PM2.5/DEP Research Project, National Institute for Environmental Studies, Japan

Keywords: nitrophenol, estrogenic activity, anti-androgenic activity, diesel exhaust particle

JOURNAL FREE ACCESS

2004 Volume 27 Issue 6 Pages 835-837

DOI https://doi.org/10.1248/bpb.27.835

Details

Abstract

We recently isolated 4-nitrophenol, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenol, and 4-nitro-3-phenylphenol from diesel exhaust particles (DEP) and identified them as vasodilators. Because these compounds are alkylphenolic derivatives that might mimic hormones, we evaluated their estrogenic activity by human estrogen receptor (hER)-yeast screen assay. All of these nitrophenol derivatives except 2-methyl-4-nitrophenol exhibited estrogenic activity. Some estrogenic compounds are also anti-androgenic, so we measured the anti-androgenic activity of the same compounds by human androgen receptor (hAR)-yeast screen assay. We found anti-androgenicity in all four nitrophenols. Nitrophenols in DEP possess not only vasodilatory activity but also estrogenic and anti-androgenic activity.

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