Clinical-alimentary tractScreening behavior of individuals at high risk for colorectal cancer
Section snippets
Study sample
The study sample was composed of individuals counseled by a clinical geneticist for the familial occurrence of colorectal cancer between 1986 and 1998 in one of the 3 family cancer clinics in Amsterdam (The Netherlands Cancer Institute, the VU University Medical Center, and the Academic Medical Center of the University of Amsterdam).
In total, 214 individuals were counseled for FCRC or HNPCC during this period. Of these, 36 were excluded because they were ultimately found to have a low risk for
Response
Of the 178 eligible individuals, 149 (84%) returned a completed questionnaire. Respondents were significantly older than nonrespondents (mean age, 45.8 vs 39.3 years; P < .01). No statistically significant differences were found between the respondents and the nonrespondents with regard to any other sociodemographic and clinical variables.
Characteristics of the study sample
Sixty-one percent of the study sample was classified as HNPCC, based on the Amsterdam criteria I (Table 2).44 Of those tested for mutation status (n = 45), 31
Discussion
The compliance rates that we observed varied between 72% (according to medical records) and 84% (based on self-report). These relatively high rates might be explained, at least in part, by the fact that all individuals had undergone genetic counseling at their own request, whereas in other studies individuals were initially invited for screening by letter17 or via an affected first-degree relative.19, 52 At the same time, however, it is important to note that we assessed repeated compliance
References (57)
- et al.
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
Gastroenterology
(1996) - et al.
Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer
Gastroenterology
(1995) - et al.
Hereditary nonpolyposis colorectal cancerresults of long-term surveillance in 50 families
Eur J Cancer
(1995) - et al.
Adherence to screening examinations for colorectal cancer after diagnosis in a first-degree relative
Prev Med
(1995) - et al.
Interest in genetic testing among first-degree relatives of colorectal cancer patients
Am J Prev Med
(2000) - et al.
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer
Gastroenterology
(2000) - et al.
Perceived risk of cancer and practice of cancer prevention behaviors among employees in an oncology center
Prev Med
(1994) - et al.
Psychological and behavioral factors associated with colorectal cancer screening among Ashkenazim
Prev Med
(1999) - et al.
Protection motivation and self-efficacya revised theory of fear appeals and attitude change
J Exp Soc Psychol
(1983) - et al.
Interval cancers in hereditary non-polyposis colorectal cancer (Lynch syndrome)
Lancet
(1995)
Determinants of persistent compliance with screening for colorectal cancer
Soc Sci Med
Family history of cancer and colon cancer riskthe Utah Population Database
J Natl Cancer Inst
Hereditary colorectal cancer
N Engl J Med
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
N Engl J Med
Screening and genetic counselling for relatives of patients with colorectal cancer in a family cancer clinic
BMJ
Guidance on large bowel surveillance for people with two first degree relatives with colorectal cancer or one first degree relative diagnosed with colorectal cancer under 45 years
Gut
A screening clinic for relatives of patients with colorectal cancer in a district general hospital
Gut
Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer
Cancer Detect Prev
Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations
Ann Intern Med
Screening and surveillance for colorectal cancer
Semin Oncol
Clinical diagnosis and management of hereditary colorectal cancer syndromes
J Clin Oncol
Participation in colorectal cancer screeninga review
J Natl Cancer Inst
Screening for colorectal cancer
Cancer Control
Cancer control problems in the lynch syndromes
Dis Colon Rectum
Feasibility of family based screening for colorectal neoplasiaexperience in one general surgical practice
Gut
A survey of screening compliance among first degree relatives of people with colon cancer in New South Wales
J Med Screen
Colon cancer screening practices after genetic counseling and testing for hereditary nonpolyposis colorectal cancer
J Clin Oncol
Genetic testing among high-risk individuals in families with hereditary nonpolyposis colorectal cancer
Br J Cancer
Cited by (89)
Body Image Perception and the Effect of Different Educational Programs on Embarrassment in Patients Undergoing Colonoscopy
2023, Journal of Perianesthesia NursingThe predicted effect and cost-effectiveness of tailoring colonoscopic surveillance according to mismatch repair gene in patients with Lynch syndrome
2022, Genetics in MedicineCitation Excerpt :Should new evidence emerge suggesting variable velocity, tailored surveillance interval will need to be considered. We considered the entirety of the population with LS and the results were aggregated on the basis of the relative proportion of each MMR gene,31 as opposed to a compartmentalized single MMR gene perspective, incorporating observed adherence rate to interval-specific colonoscopic surveillance.10,32-35 There is potential evidence that the relative distribution of each MMR gene in LS changes over time because of the complete mix of screening and detection overlay.
Worldwide Practice Patterns in Lynch Syndrome Diagnosis and Management, Based on Data From the International Mismatch Repair Consortium
2018, Clinical Gastroenterology and HepatologyHealth screening behaviors among adults with hereditary hemorrhagic telangiectasia in North America
2017, Genetics in MedicineColorectal cancer screening in the familial risk population: Is colonoscopy still the strategy of choice?
2016, Gastroenterologia y HepatologiaCitation Excerpt :Participation may be influenced by the screening test offered. Indeed, colonoscopy participation was higher in younger age groups in two studies compared with older adults.60,61 High educational level was associated with greater screening participation in three out of eight studies, but the remaining others found no such association.59
Availability and scope of integrated screening for patients with Lynch syndrome
2015, International Journal of Gynecology and Obstetrics