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Autoantibodies to β-Amyloid and Neurotransmitters in Patients with Alzheimer's Disease and Senile Dementia of the Alzheimer Type

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Abstract

The content of autoantibodies to β-amyloid protein Aβ1-42, its neurotoxic fragment Aβ25-35, and neurotransmitters were studied in the blood of patients with presenile Alzheimer's disease and senile dementia of the Alzheimer type. Significant differences in the relative content of autoantibodies to Aβ1-42 and autoantibodies to biogenic amines were demonstrated. These results can be used for the development of a biochemical method for differential diagnosis of Alzheimer dementias.

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Authors and Affiliations

  1. Laboratory of Neurochemistry and Laboratory of Immunochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region

    M. A. Myagkova, S. I. Gavrilova, N. N. Lermontova, Ya. B. Kalyn, N. D. Selezneva, G. A. Zharikov, I. V. Kolykhalov, T. V. Abramenko, T. P. Serkova & S. O. Bachurin

  2. Research and Methodological Center of Alzheimer's Disease and Associated Disorders, Center of Mental Health, Russian Academy of Medical Sciences, Moscow

    M. A. Myagkova, S. I. Gavrilova, N. N. Lermontova, Ya. B. Kalyn, N. D. Selezneva, G. A. Zharikov, I. V. Kolykhalov, T. V. Abramenko, T. P. Serkova & S. O. Bachurin

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  1. M. A. Myagkova
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  2. S. I. Gavrilova
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  3. N. N. Lermontova
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  4. Ya. B. Kalyn
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  5. N. D. Selezneva
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  6. G. A. Zharikov
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  7. I. V. Kolykhalov
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  8. T. V. Abramenko
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  9. T. P. Serkova
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  10. S. O. Bachurin
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Myagkova, M.A., Gavrilova, S.I., Lermontova, N.N. et al. Autoantibodies to β-Amyloid and Neurotransmitters in Patients with Alzheimer's Disease and Senile Dementia of the Alzheimer Type. Bulletin of Experimental Biology and Medicine 131, 127–129 (2001). https://doi.org/10.1023/A:1017527508878

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  • DOI: https://doi.org/10.1023/A:1017527508878

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