Atopic dermatitis and skin diseaseReduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants
Section snippets
Study design
The study was performed as a double-blind, placebo-controlled, randomized prospective nutritional intervention study. As reported elsewhere, the primary endpoint of the study was to elucidate whether formula feeding supplemented with a specific mixture of neutral and acidic oligosaccharides reduces the incidence of fever episodes in healthy term-born infants during the first year of life (Multicentric Infection Prevention Study (MIPS); Margriet van Stuivenberg, June 2010, unpublished data).
The
Study population
From July 2005 to December 2006, a total of 1187 infants were screened. Fifty-seven of these infants were not enrolled. A total of 1130 infants participated and were randomized into 1 of the 2 study groups or were fully breast-fed and in the BG. The intention-to-treat population was composed of 414 infants in the PG, 416 infants in the CG, and 300 infants in the BG. The trial profile is shown in Fig 1. During the observation period, 129 patients (11%) dropped out (PG, n = 53; CG, n = 42; BG,
Discussion
This trial shows that supplementation of infant formula/follow-on formula with a specific prebiotic mixture of scGOS/lcFOS/pAOS reduces the incidence of AD up to the first birthday in infants at low risk for atopy by 44% compared with the control group and down to a level similar to that of fully breast-fed infants. The severity of AD, however, was not affected significantly.
A novelty of our study is the low atopy risk strata as the target population. Primary prevention in infants at low AD
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Supported by Danone Research, Friedrichsdorf, Germany. The role of the funder has been to supply the study formulas and facilitate the data collection and data analysis.
Disclosure of potential conflict of interest: C. Grüber receives honoraria from Danone. F. Mosca receives research support from Danone/Numico. C. P. Braegger has consultant arrangements and receives research support from Danone. J. Riedler is on the advisory board for Numico and receives research support from MIPS. U. Wahn receives research support from Danone. The rest of the authors have declared that they have no conflict of interest.