Elsevier

Journal of Affective Disorders

Volume 14, Issue 2, March–April 1988, Pages 177-187
Journal of Affective Disorders

Affective changes with estrogen and androgen replacement theraphy in surgically menopausal women

https://doi.org/10.1016/0165-0327(88)90061-4Get rights and content

Abstract

Otherwise healthy surgically menopausal women who had been recieving either an intramuscular estrogen-androgen (E-A) combined preparation or estrogen alone (E) long-term had more positive moods than an untreated control group (CON) coincident with their higher levels of circulating estradiol (E2). Women who recieved both E2 and testosterone (T) felt more composed, elated, and energetic than those who were given E alone. These findings confirm that mood covaries with circulating estradiol levels in generally healthy, nondepressed women. Possible mechanisms of action of the sex steroids on affect are discussed.

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    This study was supported by Grant No. MA-8707 from The Medical Research Council of Canada awarded to B.B. Sherwin.

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