Elsevier

The Lancet

Volume 340, Issue 8833, 12 December 1992, Pages 1435-1436
The Lancet

SHORT REPORTS
Renal biopsy findings in hypertensive patients with proteinuria

https://doi.org/10.1016/0140-6736(92)92624-OGet rights and content

Abstract

27 patients with hypertension and persistent proteinuria were investigated by renal biopsy. The 13 patients without structural glomerular abnormalities were younger and had less proteinuria than the other 14, but otherwise the two groups had similar clinical features. 6 of the 14 had diffuse glomerular abnormalities; the other 8 had segmental sclerosing lesions, which were mainly in the hilum of the glomeruli, as seen in states of glomerular overload. Glomeruli in all groups were larger than those in normotensive people. It is possible that hypertension causes glomerular enlargement, proteinuria, and segmental glomerular lesions because of loss of functioning glomeruli due to ischaemia.

References (11)

  • Y. Yoshida et al.

    Glomerular haemodynamic changes vs hypertrophy in experimental glomerular sclerosis

    Kidney Int

    (1989)
  • RW. Gifford

    Evaluation of the hypertensive patient with emphasis on detecting curable causes

    Millbank Mem Q

    (1969)
  • L. Tobian

    Does essential hypertension lead to renal failure?

    Am J Cardiol

    (1987)
  • Crv Tomson et al.

    Does treated essential hypertension result in renal impairment? A cohort study

    J Hum Hypertens

    (1991)
  • PS. Kincaid-Smith

    Renal hypertension

There are more references available in the full text version of this article.

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