Effects of exercise on heart rate, QT, QTc and in the Romano-Ward inherited long QT syndrome☆
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Cited by (115)
Provocation testing in congenital long QT syndrome: A practical guide
2023, Heart RhythmCongenital Long QT Syndrome
2022, JACC: Clinical ElectrophysiologyCitation Excerpt :In cases of diagnostic uncertainty, provocation testing is often helpful for the identification of gene variant carriers.70 Provocation testing for LQTS involves assessment of repolarization in response to autonomic changes,71 particularly during the acceleration and deceleration of heart rate. Although the QT and QTc interval are known to be influenced by heart rate alterations in normal individuals,62 a maladaptive repolarization response is frequently seen in patients with LQTS.
Echocardiography-Guided Risk Stratification for Long QT Syndrome
2020, Journal of the American College of CardiologyCitation Excerpt :In a cohort of normal patients and patients with a wide variety of cardiac disease, Boudoulas et al. (11) reported that with adrenergic stimulation, changes in electromechanical systole were noted with relative prolongation of QT and shortening of QS2. Interest in this relationship was translated to LQTS when Vincent et al. (24) reported use of the QT/QS2 ratio to assist with the diagnosis of LQTS (of note, he did not specifically examine risk prediction with this ratio). Around the same time, Nador et al. (25) detected abnormalities in the pattern of ventricular posterior wall thickening of patients with LQTS, noting a remarkable difference between patients with LQTS and controls.
Impact of Updated Diagnostic Criteria for Long QT Syndrome on Clinical Detection of Diseased Patients: Results From a Study of Patients Carrying Gene Mutations
2016, JACC: Clinical ElectrophysiologyCitation Excerpt :Recently, the diagnostic criteria were updated by adding a more objective parameter, the evaluation of the recovery phase of exercise (18). Vincent et al. (13) reported that the QTc of normal subjects showed no significant changes during exercise compared with the value at rest, whereas those with Romano-Ward syndrome demonstrated a significant increase in QTc both before and after exercise. In this study, 29 of 32 patients, 31 of 36 patients, and 57 of 62 with a high probability of LQTS diagnosed by the 1993, the 2006, or the 2011 criteria, respectively, showed prolonged QTc ≥480 ms after exercise (Table 1).
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This study was supported in part by the LDS Hospital Deseret Foundation and the Marriner S. Eccles Foundation, Salt Lake City, Utah.