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Association between sudden sensorineural hearing loss and anxiety disorder: a population-based study

  • Otology
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Abstract

Anxiety disorder (AD) is commonly associated with a number of physical illnesses. No previous study has investigated the association between AD and sudden sensorineural hearing loss (SSNHL). In this study, we investigated the association between prior AD and SSNHL using a population-based dataset in Taiwan. Sampled subjects of this case–control study were retrieved from the Taiwan “Longitudinal Health Insurance Database”. We identified 3,522 patients who had a diagnosis of SSNHL as cases and 10,566 age- and gender-matched subjects without SSNHL as controls. A conditional logistic regression was used to calculate the odds ratio (OR) for having previously been diagnosed with AD between cases and controls. We found that of 14,088 patients, 13.4 % had a prior AD diagnosis, 17.8 and 11.9 % for the SSNHL group and controls, respectively. After adjusting for patient socioeconomic characteristics and comorbid medical disorders, SSNHL patients were more likely to have prior AD than the controls (OR 1.49, 95 % confidence interval (CI) 1.34–1.66, p < 0.001). Furthermore, we found that the significant relationship between SSNHL and prior AD decreased with age. The relationship was the most pronounced among those aged ≤44 years, with an adjusted OR of 1.86 (95 % CI 1.48–2.33, p < 0.001) for cases compared to controls. We concluded that patients with SSNHL had a higher proportion of prior AD than non-SSNHL-diagnosed controls. Further study is needed to confirm our findings and explore the underlying pathomechanisms.

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Authors and Affiliations

  1. Sleep Research Center, Taipei Medical University, Taipei, Taiwan

    Shiu-Dong Chung

  2. Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan

    Shiu-Dong Chung

  3. Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan

    Shih-Han Hung

  4. School of Health Care Administration, Taipei Medical University Hospital, Taipei, Taiwan

    Herng-Ching Lin

  5. Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan

    Jau-Jiuan Sheu

Authors
  1. Shiu-Dong Chung
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  2. Shih-Han Hung
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  3. Herng-Ching Lin
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  4. Jau-Jiuan Sheu
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Corresponding author

Correspondence to Jau-Jiuan Sheu.

Additional information

S.-H. Hung and S.-D. Chung have equal contributions to this study.

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Chung, SD., Hung, SH., Lin, HC. et al. Association between sudden sensorineural hearing loss and anxiety disorder: a population-based study. Eur Arch Otorhinolaryngol 272, 2673–2678 (2015). https://doi.org/10.1007/s00405-014-3235-8

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  • DOI: https://doi.org/10.1007/s00405-014-3235-8

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