Abstract
Individual differences in psychopathology, personality, and nicotine responsitivity and their biological bases are evaluated as mechanisms potentially mediating smoking heritability. Smokers are more likely to be high in neurotic traits (e.g., depression, anxiety, anger) and in social alienation (psychoticism, impulsivity, unsocialized sensation-seeking, low conscientiousness, low agreeableness) and low in achievement/socioeconomic status. Psychological and biological mechanisms putatively mediating these associations are reviewed. It is concluded that a number of relatively indirect and complex processes, as well as more direct (e.g., self-medication for psychopathology, nicotine sensitivity), mediate the inheritance of smoking behavior.
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Adler, N. E., Boyce, T., Chesney, M. A., Cohen, S., Folkman, S., Kahn, R. L., and Symme, S. L. (1994). Socioeconomic status and health.Am. Psychol. 49:15–24.
Anda, R. F., Williamson, D. F., Escobedo, L. G., Mast, E. E., Giovino, G. A., and Remington, P. L. (1990). Depression and the dynamics of smoking.JAMA 264:1541–1545.
Angst, M. S. (1979). Risikofaktoren fur starkes Zigarettenrauchen bei jungen Mannern.J. Suisse Med. 109:115–122.
Ashton, H., Millman, J. E., Telford, R., and Thompson, J. W. (1974). The effects of caffeine, nitrazepam, and cigarette smoking on the contingent negative variation in man.Electroencephalogr. Clin. Neurophysiol. 37:59–71.
Balfour, D. J. K. (1991). The neurochemical mechanisms underlying nicotine tolerance and dependence. In Pratt, J. A. (ed.),The Biological Bases of Drug Tolerance and Dependence. Academic Press, New York, pp. 121–151.
Bass, C. (1988). Personality correlates of smoking behavior in men with heart disease.Personal. Indiv. Diff. 9:397–400.
Binnie, A., and Comer, K. (1978). The effects of cigarette smoking on the contingent negative variation (CNV) and eye movement. In Thornton R., (ed.),Smoking Behaviour: Physiological and Psychological Influences, Churchill Livingstone, Edinburgh, pp. 69–75.
Brackenridge, C. J., and Bloch, S. (1972). Smoking in medical students.J. Psychosom. Res. 16:35–40.
Breslau, N., Kilbey, M. M., and Andreski, P. (1991). Nicotine dependence, major depression, and anxiety in young adults.Arch. Gen. Psychiat. 48:1069–1074.
Breslau, N., Kilbey, M. M., and Andreski, P. (1992). Nicotine withdrawal symptoms and psychiatric disorders: Findings from an epidemiologic study of young adults.Am. J. Psychiat. 149:464–469.
Breslau, N., Kilbey, M. M., and Andreski, P. (1993). Vulnerability to psychopathology in nicotine-dependent smokers: An epidemiologic study of young adults.Am. J. Psychiat. 150:941–946.
Breslau, N., Kilbey, M. M., and Andreski, P. (1994). DSM-III-R nicotine dependence in young adults: Prevalence, correlates, and associated psychiatric disorders.Addiction (in press).
Brook, J. S., Gordon, A. S., and Brook, D. W. (1987). Fathers and daughters: Their relationship and personality characteristics associated with the daughter's smoking behavior.J. Genet. Psychol. 148:31–44.
Brook, J. S., Whiteman, M., Gordon, A. S., and Brook, D. W. (1983). Fathers and sons: Their relationship and personality characteristics associated with the son's smoking behavior.J. Genet. Psychol. 142:271–281.
Carey, G., and DiLalla, D. L. (1994). Personality and psychopathology: Genetic perspectives.J. Abnorm. Psychol. 103:32–43.
Carmelli, D., Swan, G. E., Robinette, D., and Fabsitz, R. R. (1990). Heritability of substance use in the NAS-NRTC Twin Registry.Acta Genet. Med. Gemello. (Roma) 39:91–98.
Carmelli, D., Swan, G. E., Robinette, D., and Fabsitz, R. R. (1992). Genetic influence on smoking—A study of male twins.N. Engl. J. Med. 327:829–833.
Chassin, L., Presson, C. C., Sherman, S. Olshavsky, R. W. (1984). Predicting the onset of cigarette smoking in adolescents: A longitudinal study.J. Appl. Soc. Psychol. 14:224–243.
Cherry, N., and Kiernan, K. (1976). Personality scores and smoking behavior: A longitudinal study.Br. J. Prev. Soc. Med. 30:123–131.
Cinciripini, P. M., Lapitsky, L., Seay, S., Wallfisch, A., Meyer, W. J., and Van Vunakis, H. (1994). A placebo controlled evaluation of the effects of buspirone on smoking cessation: Differences between high and low anxiety smokers (submitted for publication).
Clarke, P. B. S. (1990). The central pharmacology of nicotine: Electrophysiological approaches. In Wonnacott, S., Russell, M. A. H., and Stolerman, I. P. (eds.),Nicotine Psychopharmacology: Molecular, Cellular and Behavioural Aspects, Oxford University Press, Oxford, pp. 158–193.
Costa, P. T., and McCrae, R. R. (1992).Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NDO-FFI) Professional Manual, Psychological Assessment Resources, Odessa, FL.
Covey, L. S., and Tam, D. (1990). Depressive mood, the single-parent home, and adolescent cigarette smoking.Am. J. Public Health 80:1330–1333.
Covey, L. S., Glassman, A. H., and Stetner, F. (1990). Depression and depressive symptoms in smoking cessation.Comp. Psychiat. 31:350–354.
Davidson, R. J. (1984). Hemispheric asymmetry and emotion. In Scherer, K. R., and Ekman, P. (eds.),Approaches to Emotion, Lawrence Erlbaum, Hillsdale, NJ, pp. 39–57.
Eaves, L. J., and Eysenck, H. J. (1980). The inheritance of smoking: Evidence from twin studies. In Eysenck, H. J. (ed.),The Causes and Effects of Smoking, Maurice Temple Smith, London, pp. 140–157.
Eaves, L. J., Eysenck, H. J., and Martin, N. (1989).Genes, Culture and Personality, Academic Press, New York.
Edwards, N. B., Simmons, R. C., Rosenthal, T. L., Hoon, P. W., and Downs, J. M. (1988). Doxepin in the treatment of nicotine withdrawal.Psychosomatics 29:203–206.
Epstein, L., and Collins, F. (1977). The measurement of situational influence of smoking.Addict. Behav. 2:47–54.
Eysenck, H. J. (1973). Personality and the maintenance of the smoking habit. In Dunn, W. L. (ed.),Smoking Behavior: Motives and Incentives, V. H. Winston, Washington, DC, pp. 113–146.
Eysenck, H. J. (1980).The Causes and Effects of Smoking. Maurice Temple Smith, London.
Eysenck, H. J., and Eysenck, M. W. (1985).Personality and Individual Differences: A Natural Sciences Approach, Plenum, New York.
Eysenck, H. J., and Eysenck, S. B. G. (1975).Manual of the Eysenck Personality Questionnaire, Educational and Industrial Testing Service, San Diego.
Eysenck, H. J., and O'Connor, K. (1979). Smoking arousal and personality. In Remond, A., and Izard, C. (eds.),Electrophysiological Effects of Nicotine, Elsevier/North Holland, Amsterdam, pp. 147–157.
Gilbert, D. G. (1987). Effects of smoking and nicotine on EEG lateralization as a function of personality.Personal. Indiv. Diff. 8:933–941.
Gilbert, D. G. (1988). EEG and personality differences between smokers and nonsmokers.Personal. Indiv. Diff. 9:659–665.
Gilbert, D. G. (1991). A personality × personality × setting biosocial model of interpersonal affect and communication. In Gilbert, D. G., Connolly, J. J. (eds.),Personality, Social Skills, and Psychopathology: An Individual Differences Approach, Plenum, New York, pp. 107–135.
Gilbert, D. G. (1995).Smoking; Individual Differences, Psychopathology, and Emotion, Taylor & Francis, Washington, D.C.
Gilbert, D. G., and Hagen, R. L. (1985). Electrodermal responses tomovie stressors: Nicotine × extraversion interactions.Personal. Indiv. Diff. 6:573–578.
Gilbert, D. G., and Welser, R. (1989). Emotion, anxiety and smoking. In Ney, T., and Gale, A. (eds.),Smoking and Human Behavior, Wiley, Chichester, pp. 171–196.
Gilbert, D. G., Robinson, J. H., Chamberlin, C. L., and Spielberger, C. D. (1989). Effects of smoking/nicotine on anxiety, heart rate, and lateralization of EEG during a stressful move.Psychophysiology 26:311–320.
Gilbert, D. G., Meliska, C. J., Welser, R., Scott, S., Jensen, R. A., and Meliska, J. (1992).Individual differences in the effects of smoking cessation on EEG, mood and vigilance. Paper presented at the Thirteenth Annual Meeting of the Society of Behavioral Medicine, New York, Mar.
Gilbert, D. G., Gehlbach, B., Estes, S. L., Rabinovich, N., and Detwiler, R. J. (1994a).Effects of smoking deprivation and a quantified dose of tobacco smoke on EEG power and lateralization as a function of depression and habitual nicotine intake. Paper presented at the Thirty—Fourth Annual Meeting of the Society for Psychophysiological Research, Atlanta, GA.Psychophysiology 31:S50 (abstr.).
Gilbert, D. G., Meliska, C. J., Welser, R., and Estes, S. L. (1994b). Depression, personality, and gender influence EEG, cortisol, beta-endorphin, heart rate, and subjective responses to smoking multiple cigarettes.Personal. Indiv. Diff. 16:247–264.
Glassman, A. H. (1993). Cigarette smoking: Implications for psychiatric illness.Am. J. Psychiatr. 150(86):507–510.
Glassman, A. H., Jackson, W. K., Walsh, B. T., Roose, S. P., and Rosenfeld, B. (1984). Cigarette craving, smoking withdrawal and clonidine.Science 226:864–867.
Glassman, A. H., Helzer, J. E., Covey, L. S., Cottler, L. B., Stetner, F., Tipp, J. E., and Johnson, M. (1990). Smoking, smoking cessation, and major depression.JAMA 264:1546–1549.
Glynn, S. H., and Sussman, S. (1990). Why patients smoke (letter).Hosp. Commun. Psychiat. 41:1027.
Goff, D. C., Henderson, D. C., and Amico, E. (1992). Cigarette smoking in schizophrenia: Relationship to psychopathology and medication side effects.Am. J. Psychiat. 149:1189–1194.
Golding, J. F. (1988). Effects of cigarette smoking on resting EEG, visual evoked potential and photic driving.Pharmacol. Biochem. Behav. 29:23–32.
Golding, J., and Mangan, G. L. (1982). Arousing and de-arousing effects of cigarette smoking under conditions of stress and mild sensory isolation.Psychophysiology 19:449–456.
Golding, J. F., Harpur, T., and Brent-Smith, H. (1983). Personality, drinking and drug-taking correlates of cigarette smoking.Personal. Indiv. Diff. 6:703–706.
Gopalaswamy, A. K., and Morgan, R. (1986). Smoking in chronic schizophrenia (letter).Br. J. Psychiat. 149:523.
Gray, J. A. (1981). A critique of Eysenck's theory of personality. In Eysenck, H. J. (ed.),A Model for Personality Springer, New York, pp. 246–276.
Guilford, J. S. (1966).Factors related to successful abstinence from smoking: Final report. U.S. Public Health Service, Division of Chronic Diseases, Bureau of State Services, Washington, DC.
Gynther, L., Hewitt, J. K., Heath, A. C., and Eaves, L. (1993, July).Genetic and environmental influences on smoking and motives for smoking. Proceedings of the Twenty-Third Annual Meeting of the Behavior Genetics Association, Sidney, Australia, p. 27.
Hannah, M. C., Hopper, J. L., and Mathews, J. D. (1985). Twin concordance for a binary trait. II. Nested analysis of ever-smoking and ex-smoking traits and unnested analysis of a “committed smoking” trait.Am. J. Hum. Genet. 37:153–165.
Heath, A. C., and Madden, P. A. F. (1995). Genetic influences on smoking behavior. In Turner, J. R., Cardon, L. R., and Hewitt, J. K. (eds.), Behavior Genetic Applications in Behavioral Medicine Research, Plenum, New York (in press).
Hughes, J. R. (1986). Genetics of smoking: A brief review.Behav. Ther. 17:335–345.
Hughes, J. R., Hatsukami, D. K., Mitchell, J. E., and Dahlgren, L. A. (1986). Prevalence of smoking among psychiatric outpatients.Am. J. Psychiat. 143:993–997.
Imperato, A., Puglisi-Allegra, S., Casolini, P., Zocchi, A., and Angelucci, L. (1989). Stress-induced enhancement of dopamine and acetylcholine release in limbic structure, role of corticosterone.Eur. J. Pharmacol. 165:337–339.
Istvan, J., and Matarazzo, J. D. (1984). Tobacco, alcohol, and caffeine use: A review of their interrelationships.Psychol. Bull. 95:301–326.
Kandel, D. B., and Davies, M. (1986). Adult sequelae of adolescent depressive symptoms.Arch. Gen. Psychiat. 43:255–262.
Kaprio, J., Hammer, N., Koskenvuo, M., Floderns-Myrhed, B., Langinvainia, H., and Sarna, S. (1982). Cigarette smoking and alcohol use in Finland and Sweden: A cross-national twin study.Int. J. Epidemiol. 11:378–386.
Kellam, S. G., Ensminger, M. E., and Simon, M. B. (1980). Mental health in first grade and teenage drug, alcohol, and cigarette use.Drug Alcohol Depend. 5:273–304.
Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., and Eaves, L. J. (1992). Major depression and generalized anxiety disorder: Same genes, (partly) different environments?Arch. Gen. Psychiat. 49:716–722.
Kendler, K. S., Neale, M. C., MacLean, C. J., Heath, A. C., Eaves, L. J., and Kessler, R. C. (1993). Smoking and major depression: A causal analysis.Arch. Gen. Psychiat. 50:36–43.
Kinnunen, T., Doherty, K., Militello, F. S., and Garvey, A. J. (1994). Quitting smoking and feeling blue: Nicotine replacement as an aid for the depressed (summary). Proceedings of the Society of Behavioral Medicine's Fifteenth Anniversary Meeting.Ann. Behav. Med. 16:S68.
Knott, V. J. (1979). Personality, arousal and individual differences in cigarette smoking.Psychol. Rep. 45:423–428.
Koopmans, J. R., Boomsma, D. I., van Doornen, L. J. P., and Orlebeke, J. F. (1993).Alcohol use, smoking and personality in adolescent twins. Proceedings of the Twenty-Third Annual Meeting of the Behavior Genetics Association, Sidney, Australia, July, p. 34.
Lerner, J. V., and Vicary, J. R. (1984). Difficult temperament and drug use: Analyses from the New York Longitudinal Study.J. Drug Educ. 14:1–7.
Lichtenstein, E., Antonuccio, D. O., and Rainwater, G. (1977).Unkicking the habit: The resumption of cigarette smoking. Paper presented at the annual meeting of the Western Psychological Association, Seattle, WA, Apr.
Loehlin, J. C. (1992).Genes and Environment in Personality Development, Sage, Newbury Park, CA.
Lohr, J. B., and Flynn, K. (1992). Smoking and schizophrenia.Schizo. Res. 8:93–102.
Madden, P. A., Heath, A. C., Bucholz, K. K., Dinwiddie, S. H., Dunne, M. P., and Martin, N. G. (1993).Novelty seeking and the genetic determinants of smoking initiation and problems related to alcohol use in female twins. Proceedings of the Twenty-Third Annual Meeting of the Behavior Genetics Association, Sidney, Australia, July, p. 37.
Marks, M. J., Stitzel, J. A., and Collins, A. C. (1989). Genetic influences on nicotine responses.Pharmacol. Biochem. Behav. 33:667–668.
Marlatt, G. A., and Gordon, J. R. (1980). Determinants of relapse: Implications for the maintenance of behavior change. In Davidson, P. O., and Davidson, S. M. (eds.),Behavioral Medicine: Changing Health Lifestyles, Brunner/Mazel, New York, pp. 410–452.
Marmot, M. G., Smith, G. D., Stansfeld, S., Patel, C., North, F., Head, J., White, I., Brunner, E., and Feeney, A. (1991). Health inequalities among British civil servants: The Whitehall II study.Lancet 337:1387–1393.
Martin, M. (1985). Neuroticism as predisposition toward depression: A cognitive mechanism.Personal. Indiv. Diff. 6:353–365.
Masson, C. L., and Gilbert, D. G. (1990). Cardiovascular responses to a quantified dose of nicotine as a function of personality and nicotine tolerance.J. Behav. Med. 13:505–521.
Masterson, F., and O'Shea, B. (1984). Smoking and malignancy in schizophrenia.Br. J. Psychiat. 145:429–432.
Matarazzo, J. D., and Saslow, G. (1960). Psychological and related characteristics of smokers and non-smokers.Psychol. Bull. 57:493–513.
McCrae, R. R., Costa, P. T., and Bosse, R. (1978). Anxiety, extraversion, and smoking.Br. J. Soc. Clin. Psychol. 17:269–273.
McGee, L., and Newcomb, M. D. (1992). General deviance syndrome: Expanded hierarchical evaluations at four ages from early adolescence to adulthood.J. Consult. Clin. Psychol. 60:766–776.
McManus, I. C., and Weeks, S. J. (1982). Smoking, personality and reasons for smoking.Psychol. Med. 12:349–356.
Munck, A., Guyre, P. M., and Holbrook, N. K. (1984). Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.Endocrine Rev. 5:25–44.
O'Connor, K. (1980). Individual differences in situational preference amongst smokers.Personal. Indiv. Diff. 1:249–257.
O'Farrell, T. J., Connors, G. J., and Upper, D. (1983). Addictive behaviors among hospitalized schizophrenic patients.Addict. Behav. 8:329–333.
Parks, K. R. (1984). Smoking and the Eysenck personality dimensions: An interactive model.Psychol. Med. 14:825–834.
Pauly, J. R., Grun, E. U., and Collins, A. C. (1992). Glucocorticoid regulation of sensitivity to nicotine. In Lippiello, P. M., Collins, A. C., and Gray, J. A. (eds.),The Biology of Nicotine: Current Research Issues, Raven Press, New York, pp. 121–155.
Piazza, P. V., Deminiere, J.-M., Maccari, S., Moal, M. Le, Mormede, P., and Simon, H. (1991). Individual vulnerability to drug self-administration: Action of corticosterone on dopaminergic systems as a possible pathophysiological mechanism. In Willner, P., and Scheel-Kruger, J. (eds.),The Mesolimbic Dopamine System: From Motivation to Action, Wiley, Chichester, pp. 473–495.
Pierce, J. P., Fiore, M. C., Novotny, T. E., Hatziandreu, E. J., and Davis, R. M. (1989). Trends in cigarette smoking in the United States: Educational differences are increasing.JAMA 261:56–60.
Pohl, R., Yeragani, V. K., Balon, R., Lycaki, H., and McBride, R. (1992). Smoking in patients with panic disorder.Psychiat. Res. 43:253–262.
Pomerleau, O. F., Adkins, D., and Pertschuk, M. (1978). Predictors of outcome and recidivism in smoking cessation treatment.Addict. Behav. 3:65–70.
Pomerleau, O. F., Collins, A. C., Shiffman, S., and Pomerleau, C. S. (1993). Why some people smoke and others do not: New perspectives.J. Consult. Clin. Psychol. 61:723–731.
Pritchard, W. S. (1991). The link between smoking and P: A serotonergic hypothesis.Personal. Indiv. Diff. 12:1187–1204.
Pritchard, W. S., and Kay, D. L. C. (1993). Personality and smoking motivation of U.S. smokers as measured by the state-trait personality inventory, the Eysenck Personality Questionnaire, and Spielberger's Smoking Motivation Questionnaire.Personal. Indiv. Diff. 14:629–637.
Prochazka, A. V., Petty, T. L., Nett, L., Silvers, G. W., Sachs, D. P. L., Rennard, S. I., Daughton, D. M., Grimm, R. H., and Heim, C. (1992). Transdermal clonidine reduced some withdrawal symptoms but did not increase smoking cessation.Arch. Intern. Med. 152:2065–2069.
Robinson, T. N., Killen, J. D., Taylor, C. B., Telch, M. J., Bryson, S. W., Saylor, K. E., Maron, D. J., Maccoby, N., and Farquhar, J. W. (1987). Perspectives on adolescent substance use: A defined population study.JAMA 258:2072–2076.
Rose, J. E., Ananda, S., and Jarvik, M. E. (1983). Cigarette smoking during anxiety-provoking and monotonous tasks.Addict. Behav. 8:353–359.
Rosecrans, J., and Karan, L. D. (1993). Neurobehavioral mechanisms of nicotine action: Role in the initiation and maintenance of tobacco dependence.J. Substance Abuse Treat. 10:161–170.
Russell, M. A. H. (1994).Evaluating the newest approaches to nicotine withdrawal therapy (nicotine oral inhaler, nicotine nasal spray, combination therapy). Paper presented during symposium at the Fifteenth Annual Meeting of the Society of Behavioral Medicine, Boston, Mar.
Scarr, S., and McCartney, K. (1983). How people make their own environments: A theory of genotype→environment effects.Child Dev. 54:424–435.
Schachter, S., Silverstein, B., and Perlick, D. (1977). Psychological and pharmacological explanations of smoking under stress.J. Exp. Psychol. Gen. 106:31–40.
Seltzer, C., and Oechsli, F. (1985). Psychosocial characteristics of adolescent smokers before they started smoking: Evidence of self-selection: A prospective study.J. Chron. Dis. 38:17–26.
Shiffman, S. (1982). Relapse following smoking cessation: A situational analysis.J. Consult. Clin. Psychol. 50:71–86.
Shiffman, S. A. (1986). Cluster analytic classification of smoking relapse episodes.Addict. Behav. 11:295–307.
Shiffman, S. (1989). Tobacco “chippers”: individual differences in tobacco dependence.Psychopharmacology 97:535–538.
Sieber, M. F., and Angst, J. (1990). Alcohol, tobacco and cannabis: 12-year longitudinal associations with antecedent social context and personality.Drug Alcohol Depend. 25:281–292.
Smith, G. M. (1970). Personality and smoking: A review of the empirical literature. In Hunt, W. A. (ed.),Learning Mechanisms in Smoking, Chicago, Aldine, pp. 42–61.
Smith, B. D., Wilson, R. J., and Jones, B. E. (1983). Extraversion and multiple levels of caffeine-induced arousal: Effects of overhabituation and dishabituation.Psychopysiology 20:29–34.
Spielberger, C. D. (1986). Psychological determinants of smoking behavior. In Tollison, R. D. (ed.),Smoking and Society: Toward a More Balanced Assessment, D. C. Health, Lexington, MA, pp. 89–134.
Spielberger, C. D., and Jacobs, G. A. (1982). Personality and smoking behavior.J. Personal. Assess. 46:396–403.
Spring, B., Pingitore, R., Kessler, K., Mahableshwarker, A., Bruckner, E., Kohlbeck, and Braun, J. (1993). Fluoxetine prevents withdrawal dysphoria but not anticipatory anxiety about quitting smoking. Proceedings of the fourteenth annual meeting of the Society of Behavioral Medicine.Ann. Behav. Med. 15:129.
Stanaway, R. G., and Watson, D. W. (1981). Smoking and personality: A factorial study.Br. J. Clin. Psychol. 20:213–214.
Stepney, R. (1982). Human smoking behavior and the development of dependence on tobacco smoking.Pharmacol. Ther. 15:183–206.
Surawy, C., and Cox, T. (1987). Smoking under natural conditions: a diary study.Personal. Indiv. Diff. 8:33–41.
Tucker, D. M., and Williamson, P. A. (1984). Asymmetric neural control systems in human self-regulation.Psychol. Rev. 91:185–215.
Vandenberg, S. G., Singer, S. M., and Pauls, D. L. (1986).The Heredity of Behavior Disorders in Adults and Children, Plenum, New York.
Waal-Manning, H. J., and de Hammel, F. A. (1978). Smoking habit and psychometric scores: A community study.New Zeal. Med. J. 88:188–191.
Warburton, D. M., Revell, A., and Walters, A. C. (1988). In Rand, M. J., and Thurau, K. (eds.),The Pharmacology of icotine, IRL Press, pp. 359–373.
West, R., Hajek, P., and McNeill, A. (1991). Effect of buspirone on cigarette withdrawal symptoms and short-term abstinence rates in a smokers clinic.Psychopharmacology 104:91–96.
Zelman, D. C., Brandon, T. H., Jorenby, D. E., and Baker, T. B. (1992). Measures of affect and nicotine dependence predict differential response to smoking cessation treatments.J. Consult. Clin. Psychol. 60:943–952.
Zuckerman, M. (1979).Sensation Seeking: Beyond the Optimal Level of Arousal, Erlbaum, Hillsdale, NJ.
Zuckerman, M. (1991).Psychobiology of Personality, Cambridge University Press, New York.
Zuckerman, M. (1992). What is a basic factor and which factors are basic? Turtles all the way down.Personal. Indiv. Diff. 13:675–681.
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Gilbert, D.G., Gilbert, B.O. Personality, psychopathology, and nicotine response as mediators of the genetics of smoking. Behav Genet 25, 133–147 (1995). https://doi.org/10.1007/BF02196923
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DOI: https://doi.org/10.1007/BF02196923