Sensitivities and Specificities for Detecting Serious Infection During Follow-up (n = 20) or No Serious Infection During Follow-up (n = 390) Among Children Who Had No Serious Infection at Presentation (n = 410)
| SI (n = 20) | No SI (n = 390) | Sensitivity (95% CI) | Specificity (95% CI) | Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) | LR+ | LR− | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | Yes | No | |||||||
| CRP > 20 mg/L | 9 | 11 | 182 | 208 | 45.0 (23.2–66.8) | 53.3 (48.4–58.3) | 4.7 (1.7–7.7) | 95.0 (92.1–97.9) | 1.0 (0.6–1.6) | 1.0 (0.7–1.5) |
| CRP > 80 mg/L | 5 | 15 | 52 | 338 | 25.0 (6.0–44.0) | 86.7 (83.3–90.0) | 8.8 (1.4–16.1) | 95.0 (92.1–97.9) | 1.9 (0.8–4.2) | 0.9 (0.7–1.1) |
CI, confidence interval; CRP, C-reactive protein; LR+, positive likelihood ratio; LR−, negative likelihood ratio; SI, serious infection (defined as serious illness or referral).