| Agent | FDA Pregnancy Category | Dosage | Notes |
|---|---|---|---|
| Erythromycin | B | 250–500 mg, 2–4 times/day | Long-term use in pregnancy has not been studied Bacterial resistance is diminished by combining with topical benzoyl peroxide Hepatotoxicity is associated with erythromycin estolate; not recommended for pregnancy |
| Azithromycin | B | Dosing routine may vary, eg, 250 mg, 3 times/week | Off-label indication More flexible dosing regimen for less compliant patients |
| Cephalexin | B | 500 mg twice daily | Concern for Staphylococcus resistance |
| Amoxicillin | B | 250–500 mg twice daily | Use in early pregnancy may increase risk of oral clefts |
| Trimethoprim/sulfamethoxazole | C | 160/800 mg twice per day | Exposure during the first trimester is associated with miscarriage |
| Tetracycline | D | 250–500 mg twice daily | Toxic effects on fetal teeth and bone Avoid in pregnancy |
| Minocycline or doxycycline | D | 50–100 mg | Toxic effects on fetal teeth and bone |
| once or twice per day | Avoid in pregnancy |
FDA, US Food and Drug Administration.