Table 4. Performance, Threshold Values, and Number of Women Who Would Be Sent for Screening with Thresholds That Give Sensitivities Near 90% for Each Tool
Sensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV 95% CI)AUCWomen Who Would Be Sent for Screening, n (%)
ORAI ≥594 (82–98)19 (15–25)19 (15–25)94 (82–98)0.57240 (83)
OST <690 (77–96)25 (20–32)20 (15–26)92 (82–97)0.58224 (77)
SCORE ≥488 (75–95)28 (22–34)20 (15–26)92 (82–97)0.58217 (75)
FRAX ≥4.7%90 (77–96)17 (13–23)18 (13–24)89 (76–96)0.54243 (84)
FRAX ≥6.8%66 (51–78)51 (45–58)22 (16–30)88 (81–93)0.59149 (51)
  • AUC, area under the receiver operating characteristic curve; CI, confidence interval; FRAX, Fracture Risk Assessment Tool; NPV, negative predictive value; ORAI, Osteoporosis Risk Assessment Instrument; OST, Osteoporosis Self-Assessment Tool; PPV, positive predictive value; SCORE, Simple Calculated Osteoporosis Risk Estimation.