Table 3. Performance for each tool at recommended thresholds to detect densitometric osteoporosis and number of women who would be sent for screening
Sensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)AUCPatients Who Would Be Sent for Screening, n (%)
ORAI ≥952 (37–66)67 (61–73)25 (17–34)87 (81–91)0.60104 (36)
OST <256 (41–69)69 (63–75)27 (19–37)88 (82–92)0.63101 (35)
SCORE ≥674 (59–84)42 (36–49)21 (15–28)88 (81–93)0.58174 (60)
FRAX ≥9.3%36 (23–50)73 (67–79)22 (14–33)84 (78–89)0.5581 (28)
  • AUC, area under the receiver operating characteristic curve; CI, confidence interval; FRAX, Fracture Risk Assessment Tool; NPV, negative predictive value; ORAI, Osteoporosis Risk Assessment Instrument; OST, Osteoporosis Self-Assessment Tool; PPV, positive predictive value; SCORE, Simple Calculated Osteoporosis Risk Estimation.