Table 1. Indications for the Use of Preexposure Prophylaxis Among Adult Patients with No Acute or Established HIV Infection
MSM and transgender femalesAny male sex partner in the past 6 months AND
not in a monogamous relationship with a recently tested HIV-negative partner AND
one of the following:

  • any anal sex without condoms (receptive or insertive) in the past 6 months OR

  • any STI reported or diagnosed in the past 6 months OR

  • is in an ongoing relationship with an HIV-positive man

Patients who inject drugsAny injection of drugs (not prescribed) in the past 6 months AND
one of the following:

  • any sharing of drug injection or preparation equipment in the past 6 months OR

  • treated in a methadone, buprenorphine, or suboxone program in the past 6 months OR

  • meets sexual risk criteria described above or below

Heterosexual men and womenAny sex with opposite-sex partners in the past 6 months AND
not in a monogamous relationship with a recently tested HIV-negative partner AND
one of the following:

  • is a man who has sex with both men and women* OR

  • uses condoms infrequently with a partner known to be bisexual or use IV drugs OR

  • is in an ongoing relationship with an HIV-positive partner

  • From ref. 6.

  • ↵* That is, who is behaviorally bisexual; please also see the criteria for men who have sex with men (MSM).

  • IV, intravenous; STI, sexually transmitted infection.