Table 4. Side Effects of Tenofovir/Emtricitabine7–11,21,22,39,42–45
When studied as PrEP

  • Abdominal pain

  • Nausea

  • Weight loss

  • Headache

  • Dizziness

  • Back pain

  • Bone loss without associated fracture risk

  • Elevated creatinine

When studied as part of a multidrug HIV treatment regimen

  • Lactic acidosis

  • Severe hepatomegaly with steatosis

  • Posttreatment exacerbation of hepatitis B

  • New or worsening renal failure

  • Decreased serum phosphorus

  • Bone loss without associated fracture risk

  • PrEP, preexposure prophylaxis.