Table 3. Provider Characteristics and Associations with Prescribing Metformin in Various Clinical Situations
Provider CharacteristicsPatient ScenarioOdds Ratio95% CIP ValueFDR-Adjusted P Value
Physicians* vs Pharmacists1. Controlled T2DM4.40.6–33.6.1517.4727
2. Uncontrolled T2DM, metformin 500 mg/day0.90.2–3.6.9088.9729
3. Uncontrolled T2DM, metformin 1500 mg/day1.50.5–4.6.4614.8057
4. Chronic kidney disease1.20.4–3.4.7746.9683
5. Hepatic dysfunction1.00.3–3.3.9335.9729
6. Heart failure2.50.8–7.5.1138.4270
7. Chronic obstructive pulmonary disease8.42.1–34.0028.1108
8. Alcohol abuse3.41.2–9.6.0229.2663
9. History of lactic acidosis1.40.5–4.4.5353.8236
10. Current lactic acidosis1.50.5–4.1.4438.8057
Years practicing1. Controlled T2DM1.70.7–4.2527.7221
2. Uncontrolled T2DM, metformin 500 mg/day0.60.4–1.0399.2663
3. Uncontrolled T2DM, metformin 1500 mg/day1.10.8–1.7.4990.8057
4. Chronic kidney disease0.70.5–1.1.1174.4270
5. Hepatic dysfunction1.00.7–1.5.9878.9878
6. Heart failure1.00.7–1.4.9354.9729
7. Chronic obstructive pulmonary disease1.00.6–1.8.8681.9729
8. Alcohol abuse1.10.8–1.5.7582.9683
9. History of lactic acidosis1.10.7–1.5.7199.9635
10. Current lactic acidosis1.30.9–1.8.1166.4270
Mountain West vs Midwest region1. Controlled T2DM1.60.3–10.2.6152.8789
2. Uncontrolled T2DM, metformin 500 mg/day1.70.5–5.3.3562.8057
3. Uncontrolled T2DM, metformin 1500 mg/day1.00.4–2.9.9484.9729
4. Chronic kidney disease2.40.9–6.6.0978.4270
5. Hepatic dysfunction0.70.3–1.8.4404.8057
6. Heart failure1.00.4–2.3.9486.9729
7. Chronic obstructive pulmonary disease2.60.7–9.9.1536.4727
8. Alcohol abuse0.90.4–2.3.8698.9729
9. History of lactic acidosis1.70.6–4.6.2838.7568
10. Current lactic acidosis0.70.3–1.7.4651.8057
Academic vs all other settings1. Controlled T2DM0.40–3.5.3886.8057
2. Uncontrolled T2DM, metformin 500 mg/day0.30.1–1.2.0819.4270
3. Uncontrolled T2DM, metformin 1500 mg/day0.80.3–2.2.7227.9635
4. Chronic kidney disease3.41.3–8.9.0128.2557
5. Hepatic dysfunction1.30.5–3.3.5946.8789
6. Heart failure2.51.1–5.8.0351.2663
7. Chronic obstructive pulmonary disease0.60.1–2.2.4032.8057
8. Alcohol abuse0.80.3–1.7.5036.8057
9. History of lactic acidosis1.50.6–3.7.3557.8057
10. Current lactic acidosis2.41.1–5.5.0379.2663
  • * Physicians include residents and those who have completed residency training.

  • CI, confidence interval; FDR, false discovery rate; T2DM, type 2 diabetes mellitus.