Breadth usually >6 mm |
Asymmetry |
Poor circumscription; atypical melanocytes beyond the most peripheral discrete nest of melanocytes within the epidermis |
Increased number of single atypical melanocytes within the epidermis and epithelial structures of adnexa and, in some foci, single melanocytes predominate over nests of them |
Melanocytes scattered in the upper reaches of the epidermis |
Variation in the size and shape of nests of melanocytes |
Nests of melanocytes are not equidistant |
Irregular shapes of nests of melanocytes |
Tendency of nests of melanocytes to confluence |
Failure of maturation of atypical melanocytes, with progressive descent into the dermis |
Asymmetrical, patchy distribution of melanin within the neoplasm |
Extension of atypical melanocytes far down the epithelial structures of the adnexa |
Asymmetrical distribution of inflammatory cell infiltrates of variable densities at the base of the neoplasm |