Table 3. Common Toxicities With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Adverse EventsGefitinibErlotinibAfatinib
NEJSG002IPASSFirst-SIGNALWJTOG3405OPTIMALEURTACLUX-LUNG 3
Grade 1–4Grade >3Grade 1–4Grade >3Grade 1–4Grade >3Grade 1–4Grade >3Grade 1–4Grade >3Grade 1–4Grade >3Grade 1–4Grade >3
Rash715663722985173280138916
Diarrhea3414645025412515759514
Fatigue102171281039150576171
StomatitisNANA171402220131NANA709
VomitingNANA131190NANA10NANA173
AST/ALT elevation5426NANA3011702737462NANA
  • Data are percentages.

  • ALT, alanine transaminase; AST, aspartate transaminase; NA, not available.