Table 1. Randomized Studies Comparing Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Chemotherapy in First-Line Treatment of Non-Small-Cell Lung Cancer

Study	TKI	EGFR mutations (n)	ORR (TKI vs CT) (%)	Median PFS (TKI vs CT) (months)	OS (TKI vs CT) (months/HR)
First-Signal	Gefitinib	27	84 vs 37	8.4 vs 6.7	30.6 vs 26.5
IPASS	Gefitinib	132	71 vs 47	9.8 vs 6.4	21.6 vs 21.9
NEJGSG002	Gefitinib	228	74 vs 29	10.8 vs 5.4	27.7 vs 26.6
WJTOG3405	Gefitinib	172	62 vs 32	9.2 vs 6.3	NA
OPTIMAL	Erlotinib	154	83 vs 36	13.7 vs 4.6	NA
EURTACC	Erlotinib	173	58 vs 15	9.7 vs 5.2	NA
Lux-Lung 3	Afatinib	308	56 vs 23	13.6 vs 6.9	HR: 1.12
Lux-Lung 6	Afatinib	364	67 vs 23	11 vs 5.6	HR: 0.95

CT, chemotherapy; EGFR, epidermal growth factor receptor; HR, hazard ratio; NA, not available; ORR, objective response rate; OS, overall survival; PFS, progression-free survival; TKI, tyrosine kinase inhibitor.