T0 | T1 | T2 | T3 | |
---|---|---|---|---|
NRS | 6.9 ± 1.7 | 4.8 ± 2.0* | 2.4 ± 2.6* | 2.2 ± 2.2* |
FC | 3.5 (1–20) | 1.0 (0–7)† | 0.0 (0–7)† | 0.5 (0–2)† |
ISI | 17.8 ± 5.0 | 12.8 ± 4.6* | 10.8 ± 4.4* | 8.9 ± 3.7* |
Data are presented as mean ± standard deviation or median (range).
↵* P < .01 vs baseline (T0) using repeated measures analysis of variance.
↵† P < .01 vs T0 using Wilcoxon signed rank test.
FC, frequency of nocturnal calf cramps; ISI, Insomnia Severity Index; NRS, numerical rating scale pain score; T1, 1 week after the first injection; T2, 2 weeks after the first injection; T3, 4 weeks after the first injection.