Table 2. Multivariable-Adjusted Estimates of Sustained Virologic Suppression Among Adults Initiating Combination Antiretroviral Therapy in the HIV Research Network from 2000 to 2008
VariablesAdjusted OR* for Sustained Virologic Suppression (95% CI)P Value
Setting
    Hospital-based ambulatory careReference
    Community-based ambulatory care1.26 (0.73–2.17)NS
Age (years)
    ≥50Reference
    40–490.82 (0.72–0.93)<.01
    30–390.70 (0.62–0.80)<.01
    18–290.65 (0.56–0.75)<.01
Sex
    MaleReference
    Female1.08 (0.98–1.19)NS
Race/ethnicity
    WhiteReference
    African American/Caribbean0.85 (0.77–0.94)<.01
    Hispanic1.18 (1.05–1.33)<.01
    Other1.31 (0.99–1.73)NS
HIV risk factor
    Heterosexual transmissionReference
    MSM1.14 (1.03–1.27)<.01
    IDU0.82 (0.74–0.91)<.01
    Other0.91 (0.67–1.22)NS
CD4 before ART (cells/mm3)
    <50Reference
    50–1991.16 (1.05–1.29)<.01
    200–3491.40 (1.26–1.57)<.01
    350–4991.44 (1.25–1.65)<.01
    ≥5001.27 (1.09–1.47)<.01
Log10 viral load before ART0.76 (0.73–0.80)<.01
Outpatient visits during review period (n)
    ≥4Reference
    <40.78 (0.57–1.08)NS
Type of ART
    PI only regimenReference
    NNRTI only regimen1.47 (1.35–1.60)<.01
    NNRTI and PI0.73 (0.64–0.83)<.01
    NRTI0.78 (0.68–0.90)<.01
    Other2.79 (2.15–3.63)<.01
  • * Multivariate odds ratios include adjustment for care setting, age, sex, race/ethnicity, HIV risk factor, CD4 before antiretroviral therapy (ART), log10 viral load before ART, number of outpatient visits during the review period, and ART regimen type.

  • ART, antiretroviral therapy; CD4, Cluster of Differentiation 4; CI, confidence interval; IDU, intravenous drug use; MSM, men who have sex with men; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside/nucleotide reverse transcriptase inhibitor; NS, not significant; OR, odds ratio; PI, protease inhibitor.