Including a PBRN core team member on the academic research project team to facilitate recruitment of practices to a trial is important.

A simple 1-page information sheet about the trial is extremely helpful for the recruitment process and for informing participating practices about the trial details, how it will impact the practice, and what value it provides to the practice.

Using different forums (eg, PBRN meetings, E-mail, newsletters) to advertise the trial is best.

To improve chances of successful recruitment, target practices in which there is already an interest in the trial's topic and provide incentives (eg, continuing medical education, financial incentives, quality improvement).

Considering practical factors such as size of practice, scope of practice, and resources available is necessary when determining appropriate practices to approach.

Involving primary care practices in the design of the trial and engaging them in an ongoing advisory or participatory role will improve buy-in.

For each trial, try to minimize the work required by the practice and design the intervention to cause as little disruption as possible to clinical care.

Providing adequate funding to the practices and reducing their burden of regulatory requirements is crucial.

For a successful trial, key practice clinicians and staff need adequate training at the start of and as needed throughout the trial.

Τo maintain trusting relationships, keep PBRN personnel involved in all steps that involve the practices.

Maintaining ongoing communication between the PBRN research project manager and a key contact at each participating practice is helpful.

At the completion of the trial, make sure to recognize the accomplishments and contributions of the participating practices.

Keep the trial fun and interesting.