Table 3. Pharmaceutical Management of Latent Tuberculosis Infection⁵⁸

Medication	Duration	Dose	Frequency	Total Doses (n)
Isoniazid	9 months	Adults: 5 mg/kg	Daily	270
		Children: 10–20 mg/kg^*
		Maximum dose: 300 mg
		Adults: 15 mg/kg	Twice weekly by DOT	76
		Children: 20–40 mg/kg^*
		Maximum dose: 900 mg
	6 months	Adult: 5 mg/kg	Daily	180
		Children: Not recommended
		Maximum dose: 300 mg
		Adults: 15 mg/kg	Twice weekly by DOT	52
		Children: Not recommended
		Maximum dose: 900 mg
Isoniazid and rifapentine	3 months	Adults and children >12 years:	Once weekly by DOT	12
		INH^{^†}: 15 mg/kg rounded up to nearest 50 or 100 mg; 900 mg maximum
		RPT^{^†}: 10.0–14.0 kg: 300 mg 14.1–25.0 kg: 450 mg 25.1–32.0 kg: 600 mg 32.1–49.9 kg: 750 mg ≥50 kg: 900 mg maximum
Rifampin	4 months	Adult: 10 mg/kg^{^‡}	Daily	120
Rifampin	4 months	Maximum dose: 600 mg	Daily	120

↵* The American Academy of Pediatrics recommended INH dosage.
↵† INH is formulated as 100- and 300-mg tablets. RPT is formulated as 150-mg tablets in blister packs that should be kept sealed until use.
↵‡ In the United States, the recommended latent tuberculosis infection treatment in children is a 9-month INH regimen. For latent tuberculosis infection treatment in infants, children, and adolescents when INH cannot be tolerated or the child has had contact with a patient infected with an INH-resistant but rifamycin-susceptible organism, the American Academy of Pediatrics recommends a 6-month daily rifampin dosage (180 dosages) of 10 to 20 mg/kg.
DOT, directly observed therapy; INH, isoniazid; RPT, rifapentine.