| Population | Average Dose ± Standard Deviation (Median) | ||
|---|---|---|---|
| Decrease or No Increase | Any Increase | Increase ≥10 ng/mL | |
| All | 1907 ± 1771 (1000) | 4707 ± 3856 (4000) | 5682 ± 4323 (4800) |
| Ambulatory | 2154 ± 1716 (2000) | 4229 ± 3637 (3976) | 5092 ± 4092 (4000) |
| Nursing home | 1427 ± 1709 (800) | 6103 ± 4131 (5448) | 7574 ± 4505 (6597) |
An average daily dose of about 2000 IU/day did not register a positive change in serum concentrations of 25-hydroxyvitamin D. Doses of about 4000 to 7000 IU/day were needed for meaningful increases in serum concentrations of 25-hydroxyvitamin D. The observed doses that resulted in positive changes in serum concentrations of 25-hydroxyvitamin D are far greater than the doses recommended by national agencies.