| Evaluation of disease severity |
| Quantitative HCV RNA level |
| HCV genotype |
| Serum aminotransferase levels |
| Coagulation studies |
| Complete blood count |
| Liver biopsy (optional) |
| Liver ultrasound (optional) |
| Hepatitis B surface antigen |
| Ferritin level |
| Evaluation for contraindications to treatment |
| Depression screening instrument, such as PHQ-912 |
| Alcohol abuse screening test, such as AUDIT-C13 |
| Urine drug screen |
| Urine hCG in women of childbearing age |
| HIV antibody |
| Creatinine |
| Thyroid function tests |
| Antinuclear antibody to evaluate for autoimmune hepatitis |
| Health maintenance |
| Hepatitis A antibody |
| Hepatitis B surface antibody |
AUDIT-C, AUDIT Alcohol Consumption Questionnaire; hCG, human chorionic gonadotropin; HCV, hepatitis C virus; PHQ-9, 9-item Patient Health Questionnaire; RNA, ribonucleic acid.