Table 2. Examples of Doses and Cost per Dose of Common Advanced Therapies for Inflammatory Bowel Disease
Examples by Category (US Brand Names)Dose*Cost per Dose ($)
Immunomodulator therapy
    Thiopurines
        Azathioprine (Imuran, Azasan)100 mg daily (generic, supply of 50 tablets)262.16
        Methotrexate (Rheumatrex, Trexall)25 mg/mL per week (generic, supply 2 mL solution)8.59
Biologic therapy
    Anti-tumor necrosis factor-α
        Infliximab (Remicade)100 mg intravenous every 8 weeks (brand, one dose)974.27
        Adalimumab (Humira)40 mg subcutaneous every 2 weeks (brand, 2 doses)2809.30
        Certolizumab pegol (Cimzia)400 mg subcutaneous once monthly (brand, one dose)2664.00
    Anti-α-4 integrin
        Natalizumab (Tysabri)300 mg intravenous once monthly (brand, one dose)5296.50
  • * Doses reflect only common doses and should not be used to determine starting doses.

  • Prices obtained from Medi-Span database (www.medispan.com) in October 2013.