| Variable | Comparison Groups* | Adjusted Hazard Ratio | |
|---|---|---|---|
| Point Estimate | 95% CI | ||
| Age (years) | 67 vs 52 | 2.81 | 2.48–3.18 |
| Diabetes | Yes vs no | 1.26 | 1.08–1.48 |
| Regular use of multivitamins | Yes vs no | 0.85 | 0.76–0.95 |
| Family history of colon cancer | Yes vs no | 1.37 | 1.17–1.61 |
| Education (years) | 14 vs 12 | 1.01 | 0.97–1.06 |
| Race/ethnicity | Black vs white | 1.41 | 1.18–1.67 |
| Hawaiian vs white | 1.10 | 0.85–1.44 | |
| Japanese vs white | 1.43 | 1.20–1.70 | |
| Latino vs white | 0.95 | 0.77–1.17 | |
| Body mass index (kg/m2) | 29.3 vs 22.5 | 1.10 | 1.00–1.21 |
| Alcoholic drinks per day (n) | 0.1 vs 0 | 0.99 | 0.93–1.06 |
| Regular use of NSAIDs | Not currently vs no | 0.95 | 0.83–1.10 |
| Yes vs no | 0.79 | 0.66–0.94 | |
| Pack-years of smoking (n) | 8.9 vs 0 | 1.20 | 1.05–1.38 |
| Estrogen use | Not currently vs no | 0.96 | 0.83–1.10 |
| Yes vs no | 0.78 | 0.68–0.90 | |
↵* Continuous variables were modeled using restricted cubic splines with 3 knots. Comparison groups for the continuous variables are based on the 75th percentile versus the 25th percentile.
CI, confidence interval; NSAIDS, nonsteroidal anti-inflammatory drugs.