Table 2. Absolute and Relative Contraindications for Treatment of Hepatitis C2
Absolute Contraindications*Relative Contraindications
Major uncontrolled depressive illnessFailed prior treatment (nonresponders and relapsers)
Untreated thyroid diseaseCurrent users of illicit drugs or alcohol who are willing to participate in a substance abuse program or alcohol support program
Solid-organ transplant (renal, heart, or lung)Evidence of either no or mild fibrosis on liver biopsy
Autoimmune hepatitis or other autoimmune condition known to be exacerbated by peginterferon and ribavirinAcute hepatitis C
Pregnant or unwilling to comply with adequate contraceptionCoinfection with HIV
Severe concurrent medical disease such as severe hypertension, heart failure, significant coronary heart disease, poorly controlled diabetes, chronic obstructive pulmonary diseaseYounger than 18 years of age
Age <2 yearsChronic renal disease (either requiring or not requiring hemodialysis)
Known hypersensitivity to drugs used to treat hepatitis C virusDecompensated cirrhosis
Liver transplant recipients
  • * Therapy is currently contraindicated.

  • Therapy should be individualized.

  • Treatment may be considered after depression and thyroid disease are medically stable.

  • HIV, Human Immunodeficiency Virus.