| Variable | Comparison Groups* | Adjusted Hazard Ratio | |
|---|---|---|---|
| Point Estimate | 95% CI | ||
| Age (years) | 67 vs 52 | 3.03 | 2.69–3.41 |
| Diabetes | Yes vs no | 1.12 | 0.96–1.30 |
| Regular multivitamin use | Yes vs no | 0.83 | 0.74–0.92 |
| Family history of colon cancer | Yes vs no | 1.27 | 1.08–1.51 |
| Education (years) | 16 vs 12 | 0.94 | 0.85–1.03 |
| Race/ethnicity | Black vs white | 1.18 | 0.99–1.42 |
| Hawaiian vs white | 1.39 | 1.10–1.75 | |
| Japanese vs white | 1.52 | 1.31–1.77 | |
| Latino vs white | 1.03 | 0.86–1.23 | |
| Body mass index (kg/m2) | 28.7 vs 23.8 | 1.12 | 1.04–1.21 |
| Alcoholic drinks per day (n) | 1.15 vs 0 | 1.26 | 1.13–1.41 |
| Moderate activity per day (hours) | 1.6 vs 0.4 | 0.92 | 0.83–1.02 |
| Regular aspirin use | Not currently vs no | 0.97 | 0.84–1.11 |
| Yes vs no | 0.81 | 0.71–0.92 | |
| Pack-years smoking (n) | 19.8 vs 0 | 1.06 | 0.93–1.21 |
↵* Continuous variables were modeled using restricted cubic splines with 3 knots. Comparison groups for the continuous variables are based on the 75th percentile versus the 25th percentile.
CI, confidence interval.